Exercise Slows Epigenetic Aging and Improves Cognitive Function in Cancer Survivors

Cancer survivors who underwent chemotherapy or radiotherapy in the course of putting their cancer into remission have been shown to exhibit an increased burden of senescent cells relative to healthy peers.

Fight Aging! · 19:11

№02 / 20 · Lifespan.io

Evipedia Goes Hugging Face

With more than 860 evidence reviews on health and longevity interventions, Evipedia is now probably one of the deepest online sources in this area.

Lifespan.io · 17:34

№03 / 20 · Fight Aging!

KHL Foundation Reports the Likely First Human Partial Epigenetic Reprogramming Treatments

The first human application of partial epigenetic reprogramming of aged tissues, using adeno-associated viral (AAV) vectors, was not in fact the first patient dosed in the recently launched Life Biosciences clinical trial for optic neuropathy.

Fight Aging! · 11:22

№04 / 20 · Fight Aging!

Direct Pharmacological Activation of AMPK Modestly Extends Life in Short-Lived Species

AMPK is the target of a range of interventions known to modestly slow aging in short-lived species.

Fight Aging! · 11:11

№05 / 20 · The Guardian

Jonathan the giant tortoise, 194, offers up insight into secrets of longevity

DNA analysis of oldest living land animal reveal patterns on genes that appear to protect functioning of mitochondria The ancient quest to extend human lifespan has received a boost after scientists analysed the genetic code of the world’s oldest living land animal…

The Guardian · 19:00

№06 / 20 · npj Aging

Δ133p53α, a senescence-inhibitory p53 isoform, attenuates accelerated aging in progeria mice

npj Aging · 01:00

№07 / 20 · npj Aging

Heterogeneity in surgical site infections risk among older adults: a two-center latent class prediction study

npj Aging · 01:00

№08 / 20 · GeroScience

Resolvin E1 promotes the resolution of inflammation and enhances myogenic responses during aged skeletal muscle regeneration

Efficient muscle regeneration relies on the coordinated crosstalk between muscle stem cells (MuSCs) and their surrounding niche.

GeroScience · 01:00

№09 / 20 · GeroScience

Against the “extend healthspan but not lifespan” cliché

What is the ultimate goal of biogerontology (the study of the biology of aging)? A fashionable answer these days, often encountered, is that it is to extend healthspan not lifespan. Here we argue that this is a misguided cliché.

GeroScience · 01:00

№10 / 20 · GeroScience

Association between community toilet deprivation and depression among older adults in India: a multilevel analysis of the Longitudinal Aging Study in India from 2017-2018

Community context is an important determinant of health for older and aging adults. However, much of the research examining these associations has focused on Western contexts.

GeroScience · 01:00

№11 / 20 · GeroScience

Age-related differences in neural activity and functional connectivity during self- and other-referential processing: An EEG study

Research on brain aging has largely focused on neurological disorders such as Alzheimer’s disease, mild cognitive impairment, and other forms of cognitive decline. However, relatively few studies have examined how age affects self-knowledge in healthy older adults.

GeroScience · 01:00

Also today · №12–20

№12 · GeroScience · 01:00

Dietary preference, biological aging, and incident dementia: a prospective cohort study

Dietary patterns are modifiable determinants of dementia risk, but the interactions between individual dietary preference profiles…
№13 · News-Medical · 20:15

Adults with ADHD face higher risk of developing dementia later in life

A new study led by University of Pittsburgh School of Medicine researchers finds that adults with…
№14 · News-Medical · 17:52

Researchers identify new protein regulator of muscle stem cell differentiation

Researchers at the Leibniz Institute on Aging—Fritz Lipmann Institute (FLI) in Jena and the BTU Cottbus-Senftenberg…
№15 · The Guardian · 06:00

The generation raised on sugar rations – and what their health reveals 70 years later

From blood pressure to ageing, research suggests the first 1,000 days of sugar exposure could leave…
№16 · News-Medical · 13:18

Does extra protein protect aging muscle during fasting?

A randomized trial found that alternate-day fasting reduced weight in older men, while added protein and…
№17 · Aging Cell · 12:41

Novel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan

Phenotypic screening and SAR-guided drug design identified two flavonoid-derived senolytics, SR29384 and SR31133, which selectively killed…
№18 · News-Medical · 12:19

Could speech offer a window into aging?

Research on speech clocks shows promise for aging biomarkers, connecting speech age gaps to dementia phenotypes…
№19 · Aging Cell · 12:11

Aging Affects Pancreatic α‐Cell Function and Promotes Hyperglucagonemia: Implications in Age‐Associated Diabetes

Aging induces hyperglucagonemia through direct effects on pancreatic α-cells or indirect systemic effects. This correlates with…
№20 · Aging Cell · 09:17

Endothelial TLR4 at the Crossroads of Vascular Senescence and Targeted Senotherapeutics

While Toll-like receptor 4 (TLR4) mediates essential innate immune responses, its stress-induced hyperactivation drives vascular endothelial…

Edition №94 complete

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