Increased SIRT3 Expression Improves Mitochondrial Function to Treat Intervertebral Disc Degeneration in Mice

In this follow-up interview, we speak with Gabriel Cian about how the 2060 ecosystem has evolved since last year’s Forum, what he learned from the first edition, and how he is thinking about investment, scientific credibility, health optimization, policy, and the future…

Studies tend to show that even a late life adjustment of lifestyle can meaningfully improve health and reduce mortality risk.

How far can one go, practically speaking, and in the relatively near future, to develop therapies to treat aging based on replacement of worn parts?

Carver and colleagues profile the aged mouse brain using spatial transcriptomic and imaging analysis and identify a senescence- and disease-associated microglial-linked state enriched in white matter and reduced by senotherapeutic interventions.

Single-cell spatial mapping and orthogonal approaches reveal a senescent and disease-associated microglial state that accumulates in the white matter of the aged mouse brain and is suppressed by senotherapeutic interventions.

Hi there from Day 2 of AAIC. There may be 10,200 people here at the Alzheimer’s Association International Conference — up 1,700 from last year — from 115 countries, as the association’s Maria Carrillo announced at Monday’s plenary session.

Young small intestinal epithelial-derived exosomes (young-SI-Exos) deliver miR-379-5p, which targets Usp34 to suppress the Wnt/β-catenin pathway, thereby promoting adipocyte differentiation, enhancing lipid metabolism, and increasing lipid droplets in PDGFRα+ progenitors, ultimately reversing age-related subcutaneous adipose tissue (SAT) atrophy.

Researchers analyzing data from more than 214,000 people found that dementia risk factors differ widely across countries, challenging the idea of a one-size-fits-all prevention strategy.

"Early diagnosis really does make a difference now in terms of changing the trajectory of someone's cognitive health.” —Gayatri Devi

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