Accelerated Epigenetic Aging Correlates with Later Loss of Memory Function

At a panel in Boston, senior officials announced plans to include aging in the agency’s regulatory science agenda and discussed how therapies could move toward approval. The 2026 edition of the Aging Research and Drug Discovery Meeting (ARDD) kicked off yesterday.

First generation stem cell therapies have become widespread; they are readily accessed in medical tourism clinics, and are also available for a range of issues in more regulated parts of the world.

The commensal microbes of the gut microbiome generate a range of metabolites that are beneficial or necessary to cell function.

We benchmarked 23 ageing biomarkers and 9703 protein targets for associations with mortality risk. Epigenetic, neuroimaging and functional biomarkers showed the strongest associations, outperforming proteomic organ clocks.

(Left) In young discs, Wnt signaling-replete nucleus pulposus cells secrete ECM components and, upon disc injury, cytokines to recruit myeloid cells.

TNF-α upregulates Prodh2 via p53 in COPD myoblasts, driving mitochondrial ROS–induced cGAS/STING activation and myoblast dysfunction. This metabolic-immune pathway underlies sarcopenia, positioning Prodh2 as a therapeutic target for COPD-associated muscle wasting.

Aging in Cladonema medusae disrupts tissue homeostasis and stem cell-associated dynamics, accompanied by delayed wound closure and defective blastema formation. These age-associated cellular changes culminate in incomplete functional tentacle regeneration, revealing how aging constrains regenerative capacity in a highly regenerative cnidarian.

An integrative single-cell genetic analysis prioritizes immune cell-specific genes and drug repurposing hypotheses in Alzheimer’s disease

The increasing burden of dementia highlights the need for sensitive and ecologically relevant tools for early detection and intervention. Dual-task (DT) paradigms have emerged as promising approaches for assessing cognitive-motor alterations.

A new review published in Science brings together growing evidence that the X and Y chromosomes do much more than determining biological sex. They also shape how cells function, age and respond to disease.