Global Leaders in Geroscience Convene for Biomarkers of Aging

The effects of calorie restriction and even larger effects of growth hormone receptor knockout on the lifespan of mice have proven to be hard to beat.

Why is the APOEε2 variant of the APOE gene associated with a lower risk of Alzheimer's disease and slightly longer life expectancy?

Given a wildly successful drug, the standard pharmaceutical industry playbook is to push as hard as possible to find new uses for that drug, an effort that will tend to increase publication on the topic in the academic literature.

Serial CMR demonstrated no age-related aggravation of post-MI remodeling, although old mice displayed larger baseline cardiac geometry and increased diastolic mass. Cardiovascular diseases are the leading cause of mortality worldwide, with myocardial infarction (MI) contributing significantly to this burden.

People who followed the MIND diet more closely showed slower brain shrinkage and less grey matter loss over time, with the strongest differences equivalent to about 2.5 years of delayed brain aging.

More than half of 16,000 apparently healthy adults had signs of atherosclerosis, with arterial plaques already detectable in about 1 in 13 people ages 18 to 29.

Cognitive decline is a significant concern among frail older adults. Although aerobic and resistance exercise are recommended, their implementation remains challenging due to reduced physical capacity and vitality in this population.

The Alzheimer’s risk gene APOE4 may actively damage brain blood vessels and sabotage the cellular systems that remove harmful proteins. Researchers were able to reverse some of these effects in experiments, revealing promising new targets for Alzheimer’s, Parkinson’s, and other neurodegenerative diseases.

Arranging a short stay for my husband in an aged care facility shouldn’t take dozens of calls, emails and an interstate operation involving friends I am a carer. My husband has advanced Alzheimer’s disease and lives at home with me.

Which generation will be considered “the last to die” of age-related diseases is ultimately a question of technological development and deployment. Here’s what’s been done on that front in September.