A Conservative View of the Geroscience Endeavor

An archly conservative viewpoint links establishment academia ("this thing you are doing has not yet been proven beyond all doubt to work") to the thought leadership of Big Pharma ("this thing you are doing has not yet been proven beyond all doubt…

Fight Aging! · 18:11

№02 / 19 · Fight Aging!

Possible Approaches to Engineering Better Therapeutic Delivery of Mitochondria

Mitochondrial transplantation as a form of therapy to improve mitochondrial function in aged tissues has barely started as a going concern, and only a few patients have been treated in early studies conducted to date.

Fight Aging! · 11:22

№03 / 19 · Fight Aging!

The Geomagnetic Field Influences Mitochondrial Function in Complex Ways

It is well known that electromagnetic fields affect cellular biochemistry, but the interactions are complex enough that electromagnetic therapies have yet to emerge in any robust way.

Fight Aging! · 11:11

№04 / 19 · Nature Aging

Advancing aging biomarkers and intervention discovery at the TimePie Longevity Forum

On 20–21 September 2025, the 6th TimePie Longevity Forum convened approximately 2,500 participants from 16 countries in Shanghai. Attendees spanned aging biology, biomarker development and clinical geroscience.

Nature Aging · 01:00

№05 / 19 · Aging Cell

From Regenerative to Degenerative Niche: Multicellular Crosstalk and Population Dynamics in Skeletal Muscle Aging

Aging transforms the skeletal muscle microenvironment from a balanced, regenerative niche into a maladaptive, degenerative state. This review highlights how disrupted multicellular crosstalk drives chronic inflammation, fibrosis, and neuromuscular dysfunction, ultimately compromising tissue repair and fueling sarcopenia.

Aging Cell · 07:40

№06 / 19 · Aging Cell

Targeting Ero1L by Parthenolide Alleviates Cellular Senescence and Fibrosis of Localized Scleroderma by Regulating Mitochondria‐Associated Endoplasmic Reticulum Membranes Stabilization

PTL inhibits cell senescence and alleviates fibrosis of Los by regulating Ero1L-mediated mitochondria-associated endoplasmic reticulum membranes stabilization. Mitochondrial dysfunction drives scleroderma pathogenesis. The mitochondria-associated endoplasmic reticulum membrane (MAM) regulates mitochondrial function. Parthenolide (PTL) has protective effects on mitochondria.

Aging Cell · 05:57

№07 / 19 · Aging Cell

Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs

Single-cell transcriptomic profiling across multiple organs identifies aging reshapes neutrophil differentiation from the bone marrow to peripheral tissues. Computation analysis identifies an age-enriched Neu06-IL6 neutrophil state and predicts IL-6 as one of a candidate regulator for neutrophil remodeling.

Aging Cell · 05:52

№08 / 19 · Nature Ageing

Written in development and lost in ageing: the grammar of cellular identity

Nature Ageing · 01:00

№09 / 19 · Nature Ageing

AI ‘speech clock’ assesses how fast you’re ageing from your voice

Nature Ageing · 01:00

№10 / 19 · npj Aging

A systematic review of brain health in centenarians

npj Aging · 01:00

№11 / 19 · npj Aging

Sex-specific network architecture and behavioral modulation of brain aging revealed by connectome-based predictive modeling

npj Aging · 01:00

Also today · №12–19

№12 · Peter Attia · 07:00

The end of Alzheimer’s?

A prevention strategy is in clinical trials
№13 · Aging Cell · 00:01

Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies

AMP-activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated…
№14 · GeroScience · 01:00

Associations between socioeconomic position index and epigenetic aging in NHANES

Lower socioeconomic position (SEP) is related to poor health, and epigenetic aging represents a potential mechanism…
№15 · GeroScience · 01:00

Sex- and age-specific patterns in bone, muscle, and fat across adulthood and their relation to osteosarcopenic adiposity phenotype: a cross-sectional study

Evidence suggests that age-associated differences in body composition—bone/muscle/adipose tissue—are nonlinear, but their timing, sex-specific features, and…
№16 · News-Medical · 21:14

Novel 'speech clock' can estimate a person's chronological age

A large study shows that machine-learning clocks based on speech can estimate chronological age and may…
№17 · Aging Cell · 14:15

IGF‐1/SLC25A33 Maintains Blood‐Labyrinth Barrier Integrity by Suppressing TGF‐β/Smad2‐Mediated Pericyte Activation in Age‐Related Hearing Loss

IGF-1/SLC25A33–TGF-β/Smad2 axis can regulate pericyte activation and BLB integrity, which may be a potential therapeutic target…
№18 · Aging Cell · 13:14

Dietary CoQ10 Ameliorates Age‐Related Megakaryocyte Dysfunction via COPS3‐Mediated Activation of Autophagy

Dietary CoQ10 improves megakaryocyte maturation and polyploidization and reduces platelet hyperreactivity in naturally aged mice, while…
№19 · Aging Cell · 09:34

Ghrelin Alleviates Aging‐Related Cognitive Impairment by Regulating Autophagy‐Related Signaling via the SHBG/JNK1/Beclin1 Axis in Microglia

This study found that aging-related cognitive impairment is accompanied by hippocampal microglial senescence. Ghrelin suppresses microglial…

Edition №87 complete

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