A New Metric for Overall Senescent Cell Burden

Researchers have created a deep learning-based biomarker, SASP Score, that evaluates the combined effects of the senescence-associated secretory phenotype (SASP) circulating in the bloodstream. Gathering the data needed to evaluate a person’s circulating SASP is as simple as taking a blood draw.

Lifespan.io · 20:37

№02 / 19 · Fight Aging!

PD-L1 Blockade in the Brain Restores Measures of Glial Cell Function

PD-L1 found on the surface of cells is a well known immune checkpoint protein. When it binds to the receptor PD-1 found on the surface of T cells and B cells, it acts to suppress immune activity.

Fight Aging! · 19:09

№03 / 19 · Fight Aging!

Raman Microscopy as a Potential Basis for Non-Invasive Assessment of the Burden of Senescent Cells

Researchers here provide a proof of concept for the use of Raman spectroscopy to non-invasively measure the burden of senescent cells in an imaged tissue. This works because Raman imaging can provide distinct signatures of different molecules via scattering of photons.

Fight Aging! · 11:22

№04 / 19 · Fight Aging!

Is Repeated DNA Damage Response Activation a Meaningful Cause of Aging?

One of the more interesting new concepts in aging research is that repeated activation of the DNA damage response may cause epigenetic changes in the management of nuclear DNA structure that are characteristic of aging.

Fight Aging! · 11:13

№05 / 19 · Aging Cell

Autophagy Flux Is Remodeled Sex‐ and Cell Type‐Specifically During Human Aging, and Is Linked to Reduced Physical Function in Older Adults

Autophagy-gene transcription increases with age and is uncoupled from autophagy flux. Autophagy flux is remodeled sex- and cell type-specifically and is associated with worse physical function in older adults.

Aging Cell · 05:30

№06 / 19 · Aging Cell

Deep Learning Predicts Hematopoietic Stem Cell Aging From 3D Chromatin Images

Deep learning identifies age-associated chromatin architecture signatures in 3D images of hematopoietic stem cell nuclei, providing an interpretable imaging biomarker that distinguishes young from aged cells and detects chromatin rejuvenation after treatment.

Aging Cell · 05:00

№07 / 19 · Nature Ageing

Old hearts age backwards: transplanted organs adjust to host's biological age

Nature Ageing · 01:00

№08 / 19 · Nature Ageing

Author Correction: Intermittent hypobaric pressure induces selective senescent cell death and alleviates age-related osteoporosis

Nature Ageing · 01:00

№09 / 19 · ScienceDaily Aging

Pomegranate compound improves heart function by up to 80% in study

A compound the body can make after eating pomegranates, walnuts, and some berries improved measures of heart function by up to 80% in animal models of a difficult-to-treat form of heart failure.

ScienceDaily Aging · 11:49

№10 / 19 · npj Aging

EHR-AGE: measuring biological age based on medical history data

npj Aging · 01:00

№11 / 19 · Peter Attia

#409 ‒ Inside modern drug development: the science, economics, and regulatory hurdles behind bringing new medicines to patients | Lloyd Klickstein, M.D., Ph.D.

“The way this works is… at a very high level, making a new drug that's used by many people takes longer, is more expensive, and takes as many people as building the biggest skyscraper in the world.

Peter Attia · 05:15

Also today · №12–19

№12 · GeroScience · 01:00

The effect of pectin supplementation on geriatric individuals with frailty: a randomised placebo-controlled dietary intervention study

Frailty is associated with impaired physical function, psychological decline, and alterations in the gut microbiome, yet…
№13 · GeroScience · 01:00

Hypomorphic STING1/TMEM173 variants may support immuno-metabolic resilience in aging people living with HIV

Antiretroviral therapy (ART) has significantly increased life expectancy of people living with HIV (PLWH). Nonetheless, despite…
№14 · GeroScience · 01:00

Therapeutic potential of MitoQ, a mitochondria-targeted antioxidant, in age-related physiological dysfunction

Aging is an inevitable and progressive physiological process marked by a decline in cellular function, accumulation…
№15 · GeroScience · 01:00

Gastrocnemius medialis muscle–tendon behavior during eccentric exercise in young and active older adults

Eccentric exercise is widely used in rehabilitation protocols for older adults. However, the age-related behavior of…
№16 · News-Medical · 20:19

Understanding how brain aging outside stroke injury zones affects aphasia

After a stroke, even areas of the brain that are not directly impacted by the injury…
№17 · News-Medical · 19:05

New antibody treatment blocks immune response to prevent Alzheimer's damage

There is no treatment available today to stop the death of brain cells in neurodegenerative diseases…
№18 · ScienceDaily Aging · 03:39

Scientists found a surprising driver of Alzheimer’s outside the brain

Scientists found that immune cells contributing to Alzheimer’s-related brain damage may be activated in lymph nodes…
№19 · News-Medical · 12:36

New artificial intelligence tool identifies aging patterns in hematopoietic stem cells

Aging progressively affects the functioning of our body and, among other things, deteriorates the ability of…

Edition №85 complete

Return tomorrow.
Live longer.

Aggregated longevity news, not medical advice. Consult a clinician before acting on anything you read here.