Prioritizing health interventions

Hepatocyte-specific GHR ablation is associated with hepatic and age-related pathologies, triggering adipose-liver crosstalk via elevated circulating GH and subsequent CD36-dependent hepatic steatosis.

Using 38 blood SASP proteins, a guided autoencoder-transformer model generates a composite SASP Score that captures systemic cellular senescence burden. The score predicts mortality and age-related diseases, outperforms individual proteins, and supports cross-platform biomarker translation.

Aging Cell, Volume 25, Issue 10, October 2026.

Diet is an environmental factor influencing aging and life expectancy. Age-associated DNA methylation and epigenetic clocks are primary hallmarks of aging and may be modified by diet. However, observed associations between diet and epigenetic clocks may be confounded by familial factors.

Motor changes are increasingly recognized as part of the Alzheimer’s disease (AD) phenotype, yet motor speech function and its clinical utility for early AD risk stratification remain underexplored.

In response to constant homeostatic threats, organisms have developed complex regulatory networks to monitor cellular functions and restore normal function.

Aging is the primary risk factor for neurodegenerative disease, yet the protein signatures that distinguish physiological brain aging from pathological decline remain incompletely defined in translational models.