Giving Cells Fresh Mitochondria Helps Clear Damaged Ones

Researchers have discovered that BNIP3, which regulates mitochondrial maintenance, is increased with aging, harming the heart’s ability to process energy. Mitochondrial transplantation was found to be effective against this increase in a mouse model.

Lifespan.io · 19:43

№02 / 25 · Fight Aging!

Proposing a Novel Set of Proxy Measures of Aging Rate

It is well understood in the aging research community that the lack of a useful, consensus measure of biological age or pace of biological aging is a considerable hindrance to progress.

Fight Aging! · 19:13

№03 / 25 · Fight Aging!

Naked Mole Rat Hyaluronan Synthase 2 Improves Health in Mice But Doesn't Reduce Age-Related Hearing Loss

Researchers have started on the long process of transferring promising genes from long-lived species into short-lived species, one by one, with each such transfer as a test of how important that specific difference is to the progression of aging and species longevity.

Fight Aging! · 11:22

№04 / 25 · Fight Aging!

Investigating Mechanisms by Which Mitochondrial Superoxide Promotes Longevity

Many approaches to modestly slow aging in short-lived species involve a mild mitochondrial dysfunction that that somewhat increases the level of reactive oxygen species generated in the course of producing adenosine triphosphate (ATP) to power the cell.

Fight Aging! · 11:11

№05 / 25 · Nature Aging

A cross-species single-cell kidney epigenome atlas reveals epithelial-dominant aging-like states in disease

Jeong, Lake and colleagues map changes in the human and mouse kidney DNA methylomes at single-cell resolution across disease and aging, respectively. They identify disease-associated epithelial states with epigenetic age acceleration, altered DNA methylation and chromatin compartments and spatially localized repair programs.

Nature Aging · 01:00

№06 / 25 · Nature Aging

Multi-modality profiling identifies Neisseria flavescens as a central geroprotective oral commensal in humans

Chen, Ren, Zhou, Wang et al. use the generative framework AURORA to link the oral commensal Neisseria flavescens to decelerated aging in humans. In worms and mice, live and heat-killed supplementation, respectively, are geroprotective.

Nature Aging · 01:00

№07 / 25 · Nature Aging

Publisher Correction: Physical activity delays ovarian aging in part through adiponectin-related signaling pathways

Nature Aging · 01:00

№08 / 25 · Aging Cell

The Role of EVs in the Aging Hematopoietic System

Extracellular vesicles from aged bone marrow carry pro-inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles therefore represent both a readout of hematopoietic aging and a potential therapeutic route.

Aging Cell · 05:49

№09 / 25 · GeroScience

Life’s Simple 7, depressive symptoms, cognitive performance, and their associations with all-cause mortality among middle-aged urban adults

Cardiovascular health, depressive symptoms, and cognitive performance are closely interconnected and jointly influence all-cause mortality.

GeroScience · 01:00

№10 / 25 · GeroScience

Frailty trajectories and cardiovascular disease in adults with CKM stages 0–3

Frailty reflects multidimensional biological and functional decline beyond conventional cardiometabolic risk markers. However, evidence remains limited on the associations of baseline frailty status and longitudinal frailty index trajectories with cardiovascular disease (CVD) outcomes in adults with early cardiovascular-kidney-metabolic (CKM) syndrome.

GeroScience · 01:00

№11 / 25 · News-Medical

Mount Sinai researchers discover how Alzheimer's gene damages blood vessels

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

News-Medical · 19:58

Also today · №12–25

№12 · News-Medical · 19:41

Review explores biological strategies of organisms with exceptional longevity

A new review was published in Volume 18 of Aging on September 8, 2026, titled "How…
№13 · News-Medical · 15:21

Lund University gets $19.4 million grant for Alzheimer’s blood test

Alzheimer’s researcher Sebastian Palmqvist has been awarded USD 19.4 million (SEK 190 million) from the US…
№14 · Aging Cell · 12:27

Motor Cortex Hyperexcitability Is Coupled to Neuromuscular Dysfunction in Aged Mice

Aged mice exhibited impaired motor behavior and neuromuscular hypoexcitability, yet cortical output to muscle was enhanced…
№15 · Aging Cell · 12:24

Associations Between Gut Microbiota and Immune Profiles in Community‐Dwelling Older Adults and the Regulatory Role of Polygonatum odoratum

Gut Microbiota-Immune Associations in Community-Dwelling Older Adults: Role of Polygonatum odoratum. Aging is often associated with…
№16 · Aging Cell · 12:23

Transplantation of Elderly Human Gut Microbiota Into Pigs Reprograms Intestinal Barrier Function, Plasma Metabolome, and Gut Mucosal Transcriptomic Landscape

Elderly human donor microbiota disrupts intestinal barrier integrity and reshapes host metabolic and mucosal transcriptional profiles…
№17 · Aging Cell · 12:22

Inhibition of Abnormal Elevated α‐Synuclein Ameliorates Dopaminergic Neuron Degeneration in Parkinson's Disease Mouse Model

α-Syn-HDOs protect dopaminergic neurons by enhancing BDNF–TrkB signaling through the inhibition of abnormally elevated α-Syn. These…
№18 · Aging Cell · 12:19

Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice

Rapamycin exerts multifaceted immunomodulatory effects in age-induced atherosclerosis, with pronounced inhibitory effects on adaptive immunity.
№19 · Aging Cell · 12:18

Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF‐3α‐BNIP3 Axis

Aging heart shows mitophagy flux congestion and mitochondrial dysfunction. Aberrant activation of the HIF-3α-BNIP3 axis induces…
№20 · Aging Cell · 12:17

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Mitochondrial fission-fusion imbalance contributes to age-related cardio-cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis…
№21 · Aging Cell · 12:04

Thymic Involution and Function in People With HIV and General Population Controls: A Cross‐Sectional Analysis From Two Danish Cohort Studies

Thymic involution, the age-related replacement of thymic soft tissue by fat, has been linked to immunosenescence…
№22 · Aging Cell · 11:56

Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine Senescence

Senescent cancer cells exhibit a secretory phenotype, known as SASP, capable of inducing paracrine senescence. However…
№23 · Aging Cell · 11:26

Issue Information

Aging Cell, Volume 25, Issue 10, October 2026.
№24 · ScienceDaily Aging · 13:32

Breakthrough drug reverses skin aging and dramatically speeds healing

A topical drug that removes aging, damaged cells helped older mice heal skin wounds significantly faster…
№25 · npj Aging · 01:00

A single-nucleus transcriptome atlas of cell diversity in human prefrontal cortex across the postnatal lifespan

A single-nucleus transcriptome atlas of cell diversity in human prefrontal cortex across the postnatal lifespan

Edition №81 complete

Return tomorrow.
Live longer.

Aggregated longevity news, not medical advice. Consult a clinician before acting on anything you read here.