cGAS Knockout Reduces Cellular Senescence in Aged Killifish, But Does Not Extend Life

The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction.

Fight Aging! · 19:17

№02 / 17 · Lifespan.io

Physical Activity Delays Ovarian Aging in Mice

Results from a recent study suggest a delay in ovarian aging in mice following treadmill training; this effect was mediated by adiponectin. Pharmacologically activating adiponectin receptors extended reproductive span in mice.

Lifespan.io · 19:04

№03 / 17 · Fight Aging!

Common Mechanisms of Individual Longevity Across Long-Lived Species

Researchers here take a very broad tour of the established literature on the comparative biology of aging in long lived species of all sorts, picking from those that can live more than 250 years, whether plant or animal, and comparing reported differences…

Fight Aging! · 11:22

№04 / 17 · Fight Aging!

Early Life Sugar Rationing Correlates with Better Later Life Health and Slowed Aging in Humans

Rationing of sugar in the United Kingdom in the years immediately following the Second World War forms a natural experiment in the long term effects of changes in human nutrition that can be explored in great detail given the establishment of the…

Fight Aging! · 11:11

№05 / 17 · Nature Ageing

Lsp2 links early-life diet to adult translation and lifespan in Drosophila

Nature Ageing · 01:00

№06 / 17 · Nature Ageing

Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila

Nature Ageing · 01:00

№07 / 17 · Nature Ageing

The role of senescence in kidney ageing, injury and fibrosis

Nature Ageing · 01:00

№08 / 17 · Nature Ageing

Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence

Nature Ageing · 01:00

№09 / 17 · Nature Ageing

Surprising protein links dietary restriction to increased lifespan in flies

Nature Ageing · 01:00

№10 / 17 · Nature Ageing

Mitochondrial unfoldase ClpX regulates oocyte competence during ovarian aging

Nature Ageing · 01:00

№11 / 17 · Nature Ageing

Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes

Nature Ageing · 01:00

Also today · №12–17

№12 · News-Medical · 03:36

PsychAD studies map molecular mechanisms across major brain disorders

Research led by Mount Sinai scientists within the PsychAD Consortium, a large-scale, multidisciplinary initiative launched in…
№13 · News-Medical · 03:17

Menopause leaves a blood protein signature linked to brain aging and Alzheimer’s risk

Researchers identified a 16-protein blood signature associated with menopause that tracked more strongly with reproductive hormones…
№14 · GeroScience · 01:00

Age-Related Changes in Spontaneous Brain Dynamics Revealed by Resting-State Magnetoencephalography

Spontaneous neuronal oscillations support large-scale brain communication and are sensitive to adult aging, yet how their…
№15 · GeroScience · 01:00

Ketone ester supplementation in aged mice produces sex-specific cognitive and metabolic effects

The ketogenic diet (KD) elevates β-hydroxybutyrate (β-HB), an energy metabolite and signaling molecule with immunomodulatory effects…
№16 · GeroScience · 01:00

Cardiovascular health, as per life’s essential 8, and unhealthy aging trajectories

Background Cardiovascular health (CVH) is associated with individual age-related health outcomes, but its relation to unhealthy…
№17 · GeroScience · 01:00

Intestinal oxysterol remodeling underlies severe COVID-19 in an aged hamster model

Age is a critical determinant of COVID-19 severity, yet the underlying metabolic mechanisms driving disease progression…

Edition №80 complete

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