The daily longevity edition
№78
Today’s lead
Targeting Inflammation to Treat Atherosclerosis
Like many age-related conditions, atherosclerosis is accelerated by the chronic inflammation of aging. An atherosclerotic plaque is an inflammatory environment, in which macrophage cells are overwhelmed by excess cholesterol and toxic derivatives of cholesterol.
Fight Aging! · 19:11
№02 / 18 · Lifespan.io
Intermittent Fasting Shows Promise in a Huntington’s Trial
In a pilot study, patients engaging in intermittent fasting demonstrated improvements in Huntington’s disease, a neurodegenerative condition currently considered untreatable. However, the study’s size and limitations call for more research [1].
Lifespan.io · 17:56
№03 / 18 · GeroScience
Multimodal prediction of MCI-to-dementia conversion over a two-year window
Mild cognitive impairment (MCI) represents a heterogeneous clinical state where some individuals remain stable while others progress to dementia. Identification of patients who are at high risk for near-term conversion remains a critical challenge for timely intervention.
GeroScience · 01:00
№04 / 18 · Fight Aging!
There is Such a Thing as Too Much of a Focus on the Brain in Neurodegenerative Disease
Every tissue in the body exchanges signals with every other tissue. Every tissue is dependent on specialized functions that are conducted elsewhere in the body.
Fight Aging! · 11:22
№05 / 18 · Fight Aging!
Low Cardiovascular Risk in Early Midlife Correlates with Better Late Life Health
Researchers here process data from a longitudinal study of several thousand people to show that better cardiovascular heath in the early 40s correlates with better outcomes in later old age.
Fight Aging! · 11:11
№06 / 18 · Nature Aging
RamanOmics decodes the spatial vibrational–molecular architecture of senescence in aging and repair
Zhang, Chen, Monticolo, Sorrentino and colleagues pair label-free Raman imaging with spatial and single-cell transcriptomics to probe biochemical signatures of senescence in aging and repair, identifying a lipid-linked Raman signature of p21+ cells.
Nature Aging · 01:00
№07 / 18 · Nature Aging
The chemical fingerprint of cellular senescence
Senescence has traditionally been studied largely on the basis of changes in gene expression, but senescent cells also undergo profound biochemical remodeling.
Nature Aging · 01:00
№08 / 18 · The Guardian
Get tested and talk to your partner: how to have safer sex after age 50
At 51, I want many more years of a healthy, happy sex life. So I decided to compile my own guide When I got divorced after 28 years of monogamy, I was excited to be having sex again, but had concerns.
The Guardian · 17:00
№09 / 18 · News-Medical
Chronic DNA damage response may contribute to biological aging
A new review was published in Volume 18 of Aging on August 31, 2026, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework."
News-Medical · 03:40
№10 / 18 · npj Aging
CT-based biological age as a biomarker of aging and age-related disease assessment
CT-based biological age as a biomarker of aging and age-related disease assessment
npj Aging · 01:00
№11 / 18 · npj Aging
A longitudinal Health Atlas of age-associated multisystem physiology from population health examinations in China
A longitudinal Health Atlas of age-associated multisystem physiology from population health examinations in China
npj Aging · 01:00
Also today · №12–18
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№12 · Peter Attia · 05:15
#408 ‒ AMA #89: Thyroid health: interpreting symptoms, diagnosing and treating dysfunction, and navigating the gray zone
“The goal of this podcast, of course, is then to walk people through the physiology carefully…
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№13 · GeroScience · 01:00
A two-step model of age-associated autoreactivity: B cell–intrinsic aging meets inflammaging
Aging is associated with declining protective immunity and increased autoreactivity, yet the mechanisms linking these processes…
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№14 · GeroScience · 01:00
Systemic immune-inflammation and inflammation response indices as biomarkers of lymph node metastasis and lymphovascular space invasion in vulvar squamous cell carcinoma
The objective of this study is to evaluate the systemic immune-inflammation index (SII) and systemic inflammation…
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№15 · GeroScience · 01:00
Complex, but not simple, motor tasks assessment improves detection of motor-cognitive interaction in midlife
Executive and motor function are bidirectionally linked and decline as we age, yet motor-cognitive links are…
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№16 · GeroScience · 01:00
Two-wave status patterns of handgrip strength asymmetry and low handgrip strength in relation to all-cause mortality in middle-aged and older Chinese adults
Handgrip strength asymmetry (HGSA) and low handgrip strength (LHGS) reflect distinct aspects of muscle health, but…
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№17 · News-Medical · 17:19
MIT researchers develop noninvasive way to spot aging zombie cells
As we age, some of the cells in our body enter a state of senescence, in…
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№18 · News-Medical · 13:57
High adolescent BMI linked to faster biological aging in adulthood
A study by the Faculty of Sport and Health Sciences at the University of Jyväskylä, Finland…
Edition №78 complete
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Aggregated longevity news, not medical advice. Consult a clinician before acting on anything you read here.