An Entirely New Target for Fighting Senescence

Researchers have established how a protein that is nearly absent in the literature, PTCHD4, is linked to cellular senescence.

Lifespan.io · 23:41

№02 / 24 · Fight Aging!

Telomerase Expression in the Immortal Hydra

A few species of hydra are immortal in their normal environmental conditions, meaning that function does not decline over time and mortality risk does not increase over time.

Fight Aging! · 19:22

№03 / 24 · GeroScience

Association between whole-blood NAD+ concentration and frailty in community-dwelling older adults: the Itabashi Longitudinal Study on Aging

Nicotinamide adenine dinucleotide (NAD⁺) is central to energy metabolism, redox reactions, and cellular signaling. However, human evidence linking circulating NAD⁺ concentrations to frailty remains limited. We examined the association of whole-blood NAD⁺ concentration with frailty in community-dwelling older adults.

GeroScience · 01:00

№04 / 24 · ScienceDaily Aging

Scientists reversed biological age in older adults in just 4 weeks

Older adults who changed the balance of fat, carbohydrates, and animal protein in their diets showed signs of reduced biological age after just four weeks. The strongest result appeared in participants eating an omnivorous, lower-fat, higher-carbohydrate diet.

ScienceDaily Aging · 02:35

№05 / 24 · Fight Aging!

Asymptomatic Persistent Infection as a Contribution to Degenerative Aging

Persistent infections such as cytomegalovirus and other herpesviruses most likely accelerate aging, primarily via harmful effects on the immune system that lead to earlier immunosenescence and chronic inflammation than would otherwise be the case.

Fight Aging! · 11:22

№06 / 24 · Fight Aging!

P2RX7 Antagonism Reduces Macrophage Senescence in the Aging Kidney

Cells become senescent constantly throughout life in response to various forms of damage and stress, ceasing replication and generating a potent mix of inflammatory signals.

Fight Aging! · 11:11

№07 / 24 · Aging Cell

Natural Killer Cell Dysfunction Is Emerging During Midlife Obesity

Midlife obesity was associated with impaired NK cell function, including decreased degranulation and IFN-γ production. The loss of NK cell function might explain the greater mortality risk in middle-aged individuals, highlighting the importance of monitoring immune alterations during midlife.

Aging Cell · 08:04

№08 / 24 · Nature Ageing

Age-associated loss of lymphatic vessels promotes cardiac inflammation

Nature Ageing · 01:00

№09 / 24 · Nature Ageing

Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK

Nature Ageing · 01:00

№10 / 24 · News-Medical

Why frailty and heart health may be more closely connected than we thought

A narrative review proposes cardiovascular frailty as a distinct phenotype that brings together blood pressure regulation, vascular aging, oxi-inflammaging, and clinical frailty deficits.

News-Medical · 02:15

№11 / 24 · ScienceAlert

Nasal Spray Derived From Human Placenta Protects Against Alzheimer's Decline, Study in Mice Shows

ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story, subscribe here.

ScienceAlert · 02:08

Also today · №12–24

№12 · GeroScience · 01:00

Energetic pathway to lower urinary tract symptoms in older adults: associations with cardiorespiratory fitness and walking energetics in the study of muscle, mobility and aging

Lower urinary tract symptoms (LUTS) are associated with older age and mobility limitations. We evaluated whether…
№13 · GeroScience · 01:00

The degenerating intervertebral disc leading to structural failure of the aging spine: from cellular pathways, risk factors, radiological diagnosis, to surgical management

Low back pain is a leading cause of disability worldwide. While non-specific low back pain accounts…
№14 · GeroScience · 01:00

Common and distinct plasma proteomic signature of aerobic and motor physical activity interventions and their link to episodic memory

Aging is accompanied by chronic low-grade inflammation which has been associated with cognitive decline. Physical activity…
№15 · GeroScience · 01:00

Adherence to the Mediterranean diet is associated with reduced risk of head and neck, gastric, and liver cancers: a systematic review and meta-analysis

The Mediterranean diet (MedDiet) is well established for its cardiometabolic benefits and has increasingly been linked…
№16 · GeroScience · 01:00

Dietary composition and metabolic stress differentially affect the ovarian microenvironment in mice

The ovarian microenvironment is a dynamic target of aging and highly responsive to metabolic and dietary…
№17 · GeroScience · 01:00

Association between a disease-specific frailty index and long-term quality of life outcomes in older adult patients with traumatic brain injury: a TRACK-TBI study

Traumatic brain injury (TBI) is a significant public health concern, particularly in aging populations. While advanced…
№18 · GeroScience · 01:00

Work stress and healthy aging: A conceptual framework for the Semmelweis study and the Semmelweis-EUniWell workplace health promotion model program

Chronic occupational stress is increasingly recognized as a modifiable accelerator of biological aging, yet it remains…
№19 · News-Medical · 17:40

Insilico Medicine launches AI initiative to develop longevity vaccines

Insilico Medicine, a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, today announced Longevity Vaccines, a…
№20 · News-Medical · 17:34

Study explains why Amazonian Indigenous populations show low dementia prevalence

In two Indigenous communities living pre-industrial lifestyles in the Bolivian Amazon, dementia is remarkably uncommon.
№21 · Fight Aging! · 11:22

Growth Hormone Receptor Antagonism Modestly Slows Aging in Mice

Researchers here run a much larger than usual mouse study to show a ~10% slowing of…
№22 · News-Medical · 05:24

Your voice could add something aging blood tests and scans miss

Researchers found that a standardized 30-second voice recording could predict chronological age with mean absolute errors…
№23 · Nature Ageing · 01:00

RICTOR regulates an interspecies crosstalk that influences longevity through a methionine cycle-mitophagy axis
№24 · npj Aging · 01:00

Association between loneliness and grip strength in the aging population: insights from Ardakan Cohort Study

Association between loneliness and grip strength in the aging population: insights from Ardakan Cohort Study

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