Rethinking Senescence Hallmarks in the Brain: Lessons From Peripheral Tissues and Challenges in Defining Neuronal Senescence

How screens, outdoor light, and near work may influence myopia

Semaglutide helped older healthy mice live longer while improving memory, muscle function, blood sugar control, and several biological signs of aging.

Mitochondrial DNA mutations diverge by tissue dynamics across lifespan: dividing tissues accumulate pervasive point mutations via clonal stem-cell expansion, whereas post-mitotic tissues harbor clonally expanded large-scale deletions, both culminating in age-dependent, threshold-limited respiratory failure.

Determining the age of single cells using scMLEAge

Multiple myeloma (MM) is an inflammation-driven plasma cell malignancy influenced by the bone marrow microenvironment. Dysregulated cytokine networks and neuroimmune factors may contribute to disease progression and extramedullary disease (EMD), a high-risk variant with poor prognosis.

Purpose Matrix metalloproteinases (MMPs) regulate extracellular matrix remodeling and are implicated in neurodegeneration and brain ageing. Tissue inhibitor of metalloproteinase-2 (TIMP2) has been associated with hippocampal plasticity and cognitive function.

Caloric restriction (CR) extends lifespan and delays age-related diseases in model organisms, yet its effects on biological aging in humans remain unclear.

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PTCHD4 is induced by aging- and injury-associated stresses and acts as a senescence-associated transmembrane regulator. Through AKT activation, PTCHD4 promotes cellular senescence, SASP, functional decline, and pulmonary fibrosis, whereas PTCHD4 deficiency dampens AKT signaling and alleviates senescence-associated pathological phenotypes.

Six aging clocks all said the same thing. ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story, subscribe here.