Dendritic Cell Antigen Presentation Enables T Cells to Enter the Brain and Contribute to Tau Pathology

The immune systems of the body and brain are distinct and separate, or at least largely separate, influencing one another via signaling. The blood-brain barrier keeps the vast majority of immune cells in the body out of the brain, and vice versa.

Fight Aging! · 19:16

№02 / 20 · Lifespan.io

Lung Fibrosis Drug Lowers Biological Age Estimates

Six different aging clocks detected younger blood protein profiles in patients taking the experimental lung-fibrosis drug rentosertib. This suggests possible anti-aging effects, but separating those from the narrower benefits of treating fibrosis remains a challenge [1].

Lifespan.io · 18:22

№03 / 20 · Lifespan.io

Your Personal Longevity Assistant: Evipedia Grok Bot

With Grok Bot, SpaceXAi has created something really special and helpful. And the Evipedia Grok Bot turns this gem into something even more precious. A specialized AI assistant offering an evidence-based 2nd opinion on health and longevity interventions.

Lifespan.io · 15:34

№04 / 20 · Fight Aging!

Inflammation Driven by Fat Cells as a Contribution to Atherosclerosis

Atherosclerosis is the largest cause of human mortality, producing stroke and heart attack when fatty plaques obstructing arteries rupture. There is accordingly a great deal of research aimed at influencing the course of the condition.

Fight Aging! · 11:22

№05 / 20 · Fight Aging!

Aging is Complex, So Expect High Variance in the Details Between Individuals

Aging is a complex stochastic process of damage accumulation, shaped at the detail level by choices made, environments encountered, and the responses and interactions of countless cells.

Fight Aging! · 11:11

№06 / 20 · ScienceDaily Aging

The secret to longer life may be hidden in bat DNA

Long-lived bats appear to combine powerful immune defenses with unusual strategies for eliminating damaged cells, potentially helping them avoid cancer and disease for decades. Researchers hope these genetic tricks could eventually reveal new ways to protect human health during aging.

ScienceDaily Aging · 01:25

№07 / 20 · Nature Aging

Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease

Bhattarai, Yilmaz and colleagues identify astrocyte-derived fibronectin as a key driver of blood–brain barrier dysfunction in Alzheimer’s disease, linking APOE ε4 and amyloid pathology to vascular damage and highlighting FN1 as a potential therapeutic target.

Nature Aging · 01:00

№08 / 20 · Nature Aging

European Innovation Council support for healthy aging biotechnology

Nature Aging · 01:00

№09 / 20 · Aging Cell

Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats

Using genetically heterogeneous rats carrying divergent mitochondrial haplotypes on a randomized nuclear background, we show that mtDNA variation modifies the rate of ovarian aging.

Aging Cell · 05:01

№10 / 20 · Nature Ageing

Human tau pathology is associated with lonely, nontraveling slow waves linked to memory impairment

Nature Ageing · 01:00

№11 / 20 · Nature Ageing

Osteoporosis affects millions: could modified cells rebuild their bones?

Nature Ageing · 01:00

Also today · №12–20

№12 · STAT · 16:10

Medicaid will let states use ‘tiers’ to determine medical frailty

WASHINGTON — The Centers for Medicare and Medicaid Services this week released guidance for states allowing…
№13 · npj Aging · 01:00

Tissue-specific genomics uncovers coregulators in telomere biology that affect risk of ischemic heart disease

Tissue-specific genomics uncovers coregulators in telomere biology that affect risk of ischemic heart disease
№14 · npj Aging · 01:00

Salvianolic acids are natural senolytics and increase lifespan in old age

Salvianolic acids are natural senolytics and increase lifespan in old age
№15 · npj Aging · 01:00

Sound of aging: large-scale evidence for a voice-based biological clock

Sound of aging: large-scale evidence for a voice-based biological clock
№16 · GeroScience · 01:00

Parental longevity and polygenic longevity scores in relation to ageing-related factors in a population of 70-year-olds followed over six years: The Gothenburg H70 Birth Cohort Study

As societies age, a deeper understanding of ageing-related factors that contribute to longevity is needed. We…
№17 · Aging Cell · 13:11

Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels

The identification of the glymphatic system (GS) and meningeal lymphatic vessels (mLVs) challenges the century-old “immune-privileged”…
№18 · Aging Cell · 12:39

Sustained Activation of CaMKII Promotes Skeletal Muscle Contractile Dysfunction in Aging

CaMKII exemplifies antagonistic pleiotropy in skeletal muscle. Exercise-related Ca2+/redox signals drive transient CaMKII activation supporting youthful…
№19 · Nature Ageing · 01:00

Mitochondrial oxidation of carbohydrate fuel driven by pyruvate dehydrogenase rescues stemness of aging intestinal stem cells
№20 · npj Aging · 01:00

Remote ischemic conditioning: a systemic strategy against aging

Remote ischemic conditioning: a systemic strategy against aging

Edition №68 complete

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