From World Cup Champions to Longevity Champions

Researchers have discovered and explained how calcium mishandling in muscle cells leads to long-term muscle weakness in older people. Skeletal muscle cells use calcium ions to control how and when they contract.

Every field of specialist knowledge consists of a series of concentric circles, the greatest knowledge at the center, the scientists advancing the state of the art, and the least knowledge at the outskirts, the public at large.

Aging clocks built using machine learning techniques applied to biological data are colloquially said to measure biological age, or at least aspire to measure biological age.

The accumulation of senescent cells is an important contribution to degenerative aging; the inflammatory secretions of senescent cells actively degrade tissue structure and function.

Nicotinamide adenine dinucleotide (NAD+) depletion induces mitochondrial dysfunction and cytosolic mtDNA leakage in CD8+ T cells, activating the cGAS-STING pathway and promoting a senescence-associated secretory phenotype (SASP).

Sun safety is always in season. It's important to protect your skin from sun damage throughout the year, no matter what the weather.

A cross-sectional survey of 2,094 current or recent creatine users found that women were more concentrated in shorter-duration use groups than men and reported different supplementation goals, information sources, and knowledge patterns.

With advancing age comes declines in physical, cognitive, and cardiovascular function, leading to decreased performance in activities of daily living and eventual loss of independence. Exercise may delay this decline.

Circulating folate, vitamin B12, and homocysteine reflect one-carbon (1-C) metabolism, a pathway central to methylation and cellular maintenance, but longitudinal evidence linking these biomarkers to biological aging remains limited, particularly in low- and middle-income populations.

Candidate biomarkers of biologic aging include p16INK4a (p16) expression in peripheral blood T cells, a marker of cellular senescence, and whole-blood DNA methylation (DNAm) clocks, markers of epigenetic aging.