The Adaptive Cost Hypothesis of Aging, a Viewpoint on Antagonist Pleiotropy

In a new study, semaglutide given late in life increased median lifespan in female mice by more than 12% and improved various health markers. Semaglutide’s effect possibly went beyond caloric restriction [1].

One of the goals of the Dog Aging Project is to better establish that the characteristics of aging in dogs are close enough to the characteristics of aging in humans to make the results of interventions on dog life span relevant to…

In recent years, researchers have been gathering as much data as possible on the behavior of aging clocks of various sorts. The study here is an example of the type, in which multiple proteomic clocks were assessed in large epidemiological study populations.

The muscle Timeless gene critically influences skeletal muscle, heart, and circadian rhythm aging by regulating the Timeless/Clock and Timeless/Sir2/PGC-1α pathways, with exercise acting as an upstream modulator.

The uplifting, award-winning show about a girl aging four times too fast electrified New York.

Yuancheng (Ryan) Lu is obsessed with aging. And with eyes. As he steps outside the Whitehead Institute in Cambridge, Massachusetts, his aviator glasses darken automatically in the sun. Age-related blindness runs in his family.

Starting statins soon after a type 2 diabetes diagnosis may do more than protect the heart.

With a lower fertility rate than Tokyo and the number of pensioners rapidly rising, Colombia’s capital is being forced to change the way it thinks about growing old From his wheelchair, Alberto Delgado Londoño can see over the wall of the sunlit…

Handgrip strength (HGS) is recognized as the primary characteristic of sarcopenia. Low HGS is strongly associated with morbidity, disability, and mortality. However, the neural mechanisms underlying age-related declines in HGS have not been fully elucidated.

Retinal pigment epithelium (RPE) senescence acts as a core driver of subretinal fibrosis, a major irreversible pathological feature that exacerbates age-related macular degeneration (AMD). Mitophagy is essential for maintaining RPE homeostasis during aging.