Mice With Growth Hormone Halted in Middle Age Live Longer

There are a good many affordable interventions that may well produce enough of an effect on aging to justify widespread use.

Exosomes are one category of extracellular vesicle secreted by cells, a membrane-wrapped package of molecules, one complex component of the extensive, incompletely mapped communication that takes place constantly between cells.

Some aspects of cognitive function exhibit marked declines relatively early in later life, by middle age.

Ashwin and colleagues propose a statistical framing of the epidemiological transition that categorizes global diseases into four life-stages, identifying aging-related diseases as the dominant category.

Author Correction: Destabilizing heterochromatin by APOE mediates senescence

In this “Ask Me Anything” (AMA) episode, Peter delves into the critical subject of blood pressure, which is one of the three primary causes of atherosclerosis, along with high apoB and smoking.

Insilico Medicine ("Insilico"), a clinical-stage company focused on generative AI-driven drug discovery and development, today announced the publication of a new study conducted in collaboration with an international team of scientists from Harvard Medical School, Stanford University, The Broad Institute, RWTH Aachen…

This study provides proof of concept that GH antagonism in GH-producing mice extends lifespan, supporting further investigation of GH antagonists as potential anti-aging interventions in animals and humans.

Chromatin modifications on telomeres are linked to the mode of telomere DNA replication. A coupled feedforward loop model is proposed based on these to lock the ALT cancer cells in this alternative mode of telomere replication.