The daily longevity edition
№62
Today’s lead
Secreted Frizzled‐Related Protein 2 (SFRP2) Induces Follistatin‐Like 1 (FSTL1) to Regulate Dihydrotestosterone (DHT)‐Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence
Secreted frizzled-related protein 2 (SFRP2) emerges as a critical regulator in androgenetic alopecia (AGA) by promoting stability and activity of the follistatin-like protein FSTL1, establishing a novel SFRP2–FSTL1 axis that exacerbates dihydrotestosterone (DHT)-driven pathogenic changes in dermal papilla cells (DPCs).
Aging Cell · 07:11
№02 / 7 · Peter Attia
Vaginal estrogen: a potentially life-saving therapy
Local estrogen therapy treats symptoms, prevents UTIs, is safe, and likely saves lives
Peter Attia · 12:00
№03 / 7 · npj Aging
FAβ-gal: an automated fluorescence-based quantification of the senescence-associated beta-galactosidase X-gal assay
FAβ-gal: an automated fluorescence-based quantification of the senescence-associated beta-galactosidase X-gal assay
npj Aging · 01:00
№04 / 7 · GeroScience
Longitudinal infection trajectories and biological aging acceleration in adults: a prospective cohort study
Infections remain a major cause of mortality and may threaten healthy aging. Previous studies have focused on isolated severe infections rather than longitudinal infection burden.
GeroScience · 01:00
№05 / 7 · Aging Cell
Tissue‐Level Transcriptomic Entropy Reveals Organ‐Specific Aging Patterns and Predicts Cancer Progression
Tissue-level transcriptomic entropy shows organ-specific trajectories during aging and is elevated in cancers. Across large human cohorts, higher entropy associates with proliferation, senescence, reprogramming, and poorer cancer prognosis.
Aging Cell · 12:36
№06 / 7 · Aging Cell
Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging
The beneficial gut bacterium Akkermansia muciniphila (AKK) declines with age but is enriched in healthy centenarians.
Aging Cell · 12:02
№07 / 7 · npj Aging
Paradoxical network rigidity and peripheral decoupling: age-related breakdown of adaptive postural control
Paradoxical network rigidity and peripheral decoupling: age-related breakdown of adaptive postural control
npj Aging · 01:00
Edition №62 complete
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Aggregated longevity news, not medical advice. Consult a clinician before acting on anything you read here.