Senescent Cells in Metabolic Disorders

Driven by ongoing support from their community, The Longevity Science Foundation is extending the deadline for the Invested in Her campaign to October 1, 2026, as they work toward a $250,000 fundraising target to support early-stage research into ovarian aging and menopause.

The research community remains very interested in finding novel ways to promote muscle growth with minimal side effects. Therapies that inhibit myostatin or upregulate follistatin signaling are under development, and follistatin gene therapies have been available via medical tourism for some years.

Parkinson's disease and Lewy body dementia are synucleinopathies, characterized by the spread of misfolded α-synuclein through the central nervous system. The presence of misfolded α-synuclein provokes harmful changes in cell behavior and ultimately cell death in important populations of neurons.

Reframing diseases by when they occur over the lifespan reveals that aging-related diseases now dominate the global burden in every income group. They also uniquely show increasing returns, meaning that the more we tackle them, the greater the gains.

Brain changes associated with Alzheimer’s may begin at least seven years before amyloid plaques become detectable with current PET scans. Researchers uncovered the signal by tracking healthy older adults with repeated brain imaging over nearly 20 years.

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Abstract Excessive alcohol consumption accelerates cardiovascular aging by promoting oxidative stress, inflammation, lipid dysregulation, fibrotic remodeling, and loss of ventricular-vascular reserve.

Aging is a multifaceted process where physiological metrics, such as brain age and muscle age (MA), provide deeper insights than chronological age alone. These nonlinear trajectories are heavily influenced by exogenous factors like lifestyle and nutrition.

Chemotherapy-induced bone loss represents a major clinical challenge, particularly in aging populations, yet the contribution of cellular senescence to this process and its therapeutic potential remain incompletely understood.

Dietary isoleucine restriction improves metabolic health and lifespan in animal models. It is hypothesized that shifts in branched-chain amino acid catabolism drive longevity. We investigated dietary isoleucine restriction on organismal branched-chain amino acid catabolism and its association with longevity and reproduction.