A better way to think about Zone 2

Dogs and humans may have more in common when it comes to aging than scientists realized.

Transcranial direct current stimulation (tDCS) targeting the primary motor cortex (M1) has previously been shown to enhance motor learning in older adults.

Frequent micro-awakenings during sleep were linked to higher genetic risk for Alzheimer’s in healthy middle-aged adults who had no symptoms. The discovery raises the possibility that subtle changes during sleep could offer an early warning signal years before memory problems appear.

Mechanisms of aging disrupt oxygen homeostasis through three converging processes: oxygen-cascade impairment, microvascular dysfunction, and molecular maladaptation. “Oxygenaging” integrates these domains to explain how declining oxygen delivery and utilization drive mitochondrial instability and amplify the effect of the hallmarks of aging.

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Brain diseases, including dementia, have long been studied using experimental animals such as mice. However, differences between the human and animal genomes have raised concerns that some disease mechanisms may not be fully explained by conventional animal models.

Elongation of telomeres by increasing TPP1, through genetic and pharmacological approaches, promotes hair follicle bulge stem cell mobilization and migration, leading to accelerated telogen-to-anagen transition and hair regeneration. This work identifies TPP1 as a master regulator and therapeutic target for alopecia.