Physical Activity Correlates with Reductions in TMAO, Inflammation, and Harmful Bone Remodeling

Michael Snyder, Director of the Center for Genomics and Personalized Medicine at Stanford University, is obsessed with health-tracking wearables. During our interview, he wore four wrist-worn devices – watches and bands – and two rings.

Researchers here show that a few different senolytic approaches improve the state of the population of microglia in the white matter of the brain in aged mice.

Amyotrophic lateral sclerosis (ALS) is characterized by the loss of motor neurons. Aggregation of TDP-43 is thought to be involved in producing cell death in the brain.

The cGAS-STING signaling pathway contributes to low-grade inflammation in several tissues during aging; however, its role in the ovary was unclear.

Lei and colleagues show that mitochondrial DNA leaking into the cytosol of aged oocytes activates the antiviral cGAS–STING pathway, which generates a second messenger that travels through CX37 gap junctions to surrounding granulosa cells, where it triggers a sterile inflammatory program that…

Closing the gap in Alzheimer’s disease research through the Sex | Gender in Neurodegeneration Consortium

The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti-aging interventions can be classified into six primary categories. This paper summarizes the most promising anti-aging strategies within each class.

Early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) have different clinical and neuroimaging characteristics, and non-cognitive deficits usually observed are suggestive of hypothalamic dysfunctions.

The planet is experiencing an unprecedented growth in its human population aged 65 years and older, underscoring the urgent need for comprehensive aging-centered biobehavioral data to guide public health interventions.

The locus coeruleus (LC), the earliest site of tau accumulation in Alzheimer’s disease, directly influences pupillary and vergence oculomotor systems.