Aging-related transcriptomic signatures associated with recurrence following resection of stage I lung adenocarcinoma

Glaucoma is a condition of progressive blindness driven by the death of retinal cells and degeneration of the optic nerve.

A recent study has examined whether senescence might allow cancer cells to survive oncogene withdrawal and become even more dangerous [1]. Many cancers depend heavily on a particular oncogenic signal to maintain their growth.

Properties of the extracellular matrix that supports cells change with age. Increased stiffness is common in many tissues as a result of chemical cross-linking and other changes.

The composition of the gut microbiome, the population size of each bacterial species, changes with age. Microbes that provoke inflammation increase in number, while microbes producing a range of metabolites necessary for tissue function diminish in number.

Genotoxic stress induces a progressive accelerated aging-like phenotype driven by the delayed accumulation of p16Ink4a-positive senescent cells.

Objectively measured sleep patterns were associated with multiple hallmarks of aging. Total sleep duration, deep sleep, and REM sleep were generally associated with lower risks, whereas longer WASO and sleep irregularity were associated with higher risks.

Sleep bout length and nighttime activity predict longevity in medflies

What the evidence says about their growing list of established and emerging uses

The cholinergic system is central to attention, learning, and neuroplasticity and undergoes progressive degeneration with aging. Neuroplasticity-based computerized cognitive training is a scalable, non-pharmacological strategy to support cognitive health in older adults, yet its neurobiological mechanisms remain unclear.