Cytotoxic CD4+ T Cells in Aging, Both Protective and Harmful

The immune system is very complex, and immune cells exist in a continuum of states rather than being separated into clearly demarcated pigeonholes of behavior.

Fight Aging! · 19:21

№02 / 24 · Lifespan.io

Short, Intense Exercise Elicits Beneficial Metabolic Changes

A new study compared high-intensity sprint-interval exercise with moderate-intensity exercise. The former produced larger changes in circulating protein and metabolite levels than the latter and stimulated proteins associated with cardiometabolic health benefits [1]. Short and intense vs.

Lifespan.io · 17:43

№03 / 24 · Fight Aging!

Mapping Cell Populations Reveals Distinct Stages in the Progression of Aging

This popular science article discusses recent research that categorizes age-related changes a few thousand different cell populations in the body, distinguished by transcriptional behavior.

Fight Aging! · 11:22

№04 / 24 · Fight Aging!

Proposing Restoration of Circadian Rhythm as an Approach to Treat Sarcopenia

Circadian rhythm becomes disrupted with age, and a growing body of evidence points to this form of dysfunction as a contribution to many aspects of aging.

Fight Aging! · 11:11

№05 / 24 · Nature Aging

Contractile myografts confer systemic anti-aging benefits

Cell and gene therapy are of interest to treat age-related diseases. Here the authors developed subcutaneous transplantation of autologous myocytes to form myografts.

Nature Aging · 01:00

№06 / 24 · Nature Aging

Cytotoxic CD4 + T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling

Gabandé-Rodríguez, Soto-Heredero and colleagues identify an accumulation of cytotoxic CD4+ T cells producing CCL5 in the bone marrow during aging, linked to age-associated myelopoiesis. CCR5 blockade reverses this axis and improves healthspan in aged mice.

Nature Aging · 01:00

№07 / 24 · Nature Aging

Contracting myografts mimic exercise response

Liu and colleagues have developed an innovate technique to engraft differentiated muscle tissue into subcutaneous space. The muscle graft contracts automatically and promotes systemic health benefits of exercise in the setting of aging and obesity.

Nature Aging · 01:00

№08 / 24 · Nature Aging

Loss of cGAS disrupts H3K9me3 organization and derepresses LINE1 to cause inflammaging

Age-associated inflammation, also known as inflammaging, has been associated with cGAS–STING signaling, and this pathway has been proposed as a potential therapeutic target. Unexpectedly, we find that cGAS knockout mice have a shortened median lifespan and healthspan.

Nature Aging · 01:00

№09 / 24 · ScienceDaily Aging

Scientists may have found a shortcut to calorie restriction’s anti-aging benefits

Moderate calorie restriction lowered an immune protein called C3 that appears to help drive chronic inflammation as the body ages.

ScienceDaily Aging · 14:00

№10 / 24 · Aging Cell

Aging‐Related Myocardial Susceptibility Lowers Cardiac Tolerance to Chronic Intermittent Hypoxia Through Dynamin‐Related Protein 1‐Associated Mitochondrial Vulnerability

Chronic intermittent hypoxia (CIH) induces early myocardial remodeling and senescence-associated injury without overt systolic failure in young mice. Aging-related susceptibility, modeled in vivo by Tert−/− mice and in vitro by D-gal-treated primary cardiomyocytes, amplifies CIH-associated cardiac dysfunction and cellular injury.

Aging Cell · 04:34

№11 / 24 · Nature Ageing

This pulsating muscle graft mimics benefits of exercise

Nature Ageing · 01:00

Also today · №12–24

№12 · ScienceDaily Aging · 12:30

What you eat before age 2 may affect your health 70 years later

Britain’s postwar sugar rationing created a rare natural experiment that let researchers examine how early sugar…
№13 · npj Aging · 01:00

Space weather fluctuations and epigenetic aging in an elderly male cohort from Massachusetts, USA

Space weather fluctuations and epigenetic aging in an elderly male cohort from Massachusetts, USA
№14 · npj Aging · 01:00

Sex differences in the prevalence and incidence of motoric cognitive risk syndrome: a systematic review and meta-analysis

Sex differences in the prevalence and incidence of motoric cognitive risk syndrome: a systematic review and…
№15 · GeroScience · 01:00

Linking modifiable risk factors to vascular and neurodegenerative brain changes

Dementia reflects vascular and neurodegenerative processes in late life, yet studies often examine risks and outcomes…
№16 · GeroScience · 01:00

Calcium dysregulation in neurovascular function in Alzheimer’s disease: mechanisms, therapeutic targets

Neurovascular dysfunction, characterized by impaired cerebral blood flow (CBF) autoregulation and neurovascular coupling (NVC), represents a…
№17 · STAT · 10:00

Newer shingles vaccine linked to lower heart disease risk, ‘natural experiment’ shows

The newer shingles vaccine has been turning heads since its link to lower dementia rates was…
№18 · News-Medical · 18:54

Specific brain regions found more vulnerable to dementia with Lewy bodies

Dementia with Lewy bodies is one of the most common forms of dementia in older adults…
№19 · News-Medical · 17:38

Hormone replacement therapy may reduce dementia risk for some women

Hormone replacement therapy (HRT) may reduce the risk of dementia, particularly for certain groups of women…
№20 · News-Medical · 14:56

China faces rising lung cancer deaths driven by aging population

Lung cancer is the leading cause of cancer-related death both globally and in China, accounting for…
№21 · Aging Cell · 10:45

DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling

In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR-dependent Ca2+ overload, which in turn induces endoplasmic…
№22 · News-Medical · 06:21

Nicoya is a famous blue zone. DNA aging estimates tell a more complicated story

Researchers developed a SuperLearner framework that combines established epigenetic clocks with machine learning to compare DNA…
№23 · News-Medical · 04:58

Why living to 100 may depend on far more than diet and exercise

A critical narrative review found that healthy diets, regular physical activity, strong social ties, and psychological…
№24 · npj Aging · 01:00

Independent associations of clonal hematopoiesis of indeterminate potential and mosaic Y loss with all-cause and cause-specific mortality in men

Independent associations of clonal hematopoiesis of indeterminate potential and mosaic Y loss with all-cause and cause-specific…

Edition №52 complete

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