More on L-BAIBA as a Regulator of Improved Muscle Function in Response to Exercise

One way of looking at human longevity is that it results from a greater resilience to the damage and dysfunction of aging, whether that resilience emerges from lifestyle choice or genetic differences.

Aging is so very complex that almost every research project, limited in time and resources, is by necessity restricted to just examining one tiny part of the whole process.

Interrogating the role of the microbiome in aging, here the authors utilize multi-omics human cohort data to show that the abundance of Bifidobacterium pseudocatenulatum and its metabolite 5-aminovaleric acid betaine declines with age.

Aging is heterogenous, influenced by various factors, including biological sex. Here, leveraging a large-scale human aging phenome, the authors develop sex-stratified biological clocks to interrogate aging transitions, and uncover systemic metabolic and tumor marker signatures as features of aging.

Demonstrating a role for cyclic GMP–AMP synthase (cGAS) in chromatin organization, Martinez, Morandini and colleagues report that cGAS-knockout mice exhibit compromised heterochromatin organization, LINE1 derepression, inflammation and shortened lifespan.

Patients are arriving in primary care with questions about geroscience that medicine has not prepared clinicians to answer. Here, primary care physician Dean Ariel argues that the profession should prepare for these conversations rather than leaving them to improvisation.

Older adults who received the Shingrix shingles vaccine were 24% less likely to be diagnosed with dementia over four years in a study of more than 500,000 people.

A scoping review of 54 studies found that coffee and several coffee-derived bioactive compounds influence pathways linked to skeletal muscle metabolism, including insulin signaling, mitochondrial function, oxidative stress, inflammation, glucose uptake, and protein turnover.