A Tougher Extracellular Matrix Strengthens Tendons in Rats

Senescent cells accumulate with age throughout the body, either in response to forms of damage and stress or on reaching the Hayflick limit on replication.

The various mitochondrial protein complexes are the building blocks of the electron transport chain, the complicated mechanism inside mitochondria that generates adenosine triphosphate (ATP), the chemical energy store molecule used to power cell activities.

Old fruit flies generally die from intestinal dysfunction; intestinal aging is the most important aspect of aging in this species. INDY is a longevity associated gene that has been shown to have important effects on intestinal health in flies.

This study provides novel insights into the metabolic correlates of epigenetic aging biomarkers and underscores the potential of metabolomics-informed metrics of epigenetic aging as informative indicators of physiological decline and lifestyle effects.

Aging impairs flexor tendon repair, with aged tendons showing reduced Col1a1 and Sparc expression and compromised mechanical properties.

Both too little and too much sleep may be linked to faster aging throughout the body. Researchers analyzing 23 biological aging clocks found the lowest aging levels among people sleeping about 6.4 to 7.8 hours per day.

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Incidental findings from community-based mobile low-dose CT lung screening among older adults: a multicenter retrospective observational study in China

“The disease can be reversible and that's why we make so much hay about intervening early.

Cerebral small vessel disease-induced vascular cognitive impairment (VCI) is a major contributor to the pathogenesis of dementia. Accumulating evidence suggests that VCI disrupts large-scale brain networks, but how it selectively impairs inter-network connectivity and contributes to specific cognitive deficits remains unclear.