Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels

Gum recession is common, often silent, and sometimes worsened by the very habits meant to protect your teeth.

We present LivAge, an online aging clock that estimates murine transcriptomic age from hepatic RNA-seq data. Externally validated, it detects accelerated aging in progeroid models and quantifies the effect of geroprotective interventions, providing an accurate, accessible, and ready-to-use tool for aging research.

Current practice and needs for fall prevention embedded in the national essential public health service program: a qualitative study

An epithelial-derived epigenetic clock reveals pathway-level aging mechanisms in chronic lung disease

Deletion of P311 enhances regeneration in aged skeletal muscle

Aging is a complex biological phenomenon. Because health can vary greatly even among persons of the same chronological age, biological age, an integrative measure of physiological and molecular deterioration, may be a more useful construct for promoting longevity.

hTERT immortalization stabilizes hUCMSC-derived sEV function by alleviating cellular senescence and preserving young-like cargo profiles. H11-sEVs retain immunomodulatory activity, primordial follicle-activating capacity, and ovarian protective effects.

Advanced maternal age impairs uterine decidualization via downregulated RICTOR-ATK3-FoxO1 signaling. The RICTOR agonist MHY1485 rescues decidual defects, offering a therapy for age-related pregnancy failure. Miscarriage and abnormal embryonic development in women of advanced maternal age (AMA) are often associated with impaired decidualization.

Frailty and cognitive impairments frequently co-occur in older adults. It remains unclear whether this overlap reflects shared underlying biological mechanisms or parallel but distinct disease pathways.