TIMP2 Protein Therapy Favorable Adjusts the Behavior of Microglia in the Aging Brain

How age and sex interaction is associated with immune aging with implications for vaccines and age-related autoimmunity

A new study suggests that in amyotrophic lateral sclerosis – and possibly other neurodegenerative diseases – the brain’s immune cells devour stressed but still living neurons due to altered signaling [1].

The retina is a part of the central nervous system, and as such is subject to a variety of forms of age-related neurodegeneration, culminating in conditions such as macular degeneration.

Histological studies investigate the fine structure of tissues, usually thinly sliced and mounted on slides, stained in ways that emphasis specific features, and imaged via a microscope.

Hidden hearing loss during aging is associated with peripheral auditory system decline. We discovered that aging sensory hair cells decrease in size.

Findings from this study suggest that aging is accompanied by altered skeletal muscle mitochondrial redox regulation and exercise responsiveness, with decreased mtDNA copy number, increased mtDNA mutation deletion frequency, and selective redox remodeling of key mitochondrial proteins representing potential contributors to these…

Transcriptomic analysis using a rabbit glaucoma filtration surgery model, combined with in vitro experiments on human conjunctival fibroblasts, demonstrates that mitomycin C induces a senescence-associated secretory phenotype (SASP)-like state.

Multi-omics profiling reveals that aging impairs stem/progenitor cell differentiation and taste bud regeneration in the posterior tongue. Age-related macrophage polarization remodeling, marked by the accumulation of pro-inflammatory M1 macrophages, contributes to a Thbs1-enriched inhibitory niche that limits taste cell growth and differentiation.

Ageing profoundly alters the thymic microenvironment, but its impact on T-cell receptor (TCR) repertoire selection remains unclear.

Aging Cell, Volume 25, Issue 9, September 2026.