How Old Fat Cells Trigger Inflammation and Raise Risks

RANKL is best studied in the context of bone remodeling. Its activity, binding to the cell surface receptor RANK, is necessary for the function of the osteoclast cells that break down bone extracellular matrix.

Epigenetic changes, such as DNA methylation (DNAm), offer a measure of biological age distinct from chronological age. DNAm PhenoAge is one such biomarker that is more strongly related to morbidity, mortality, and physical function than chronological age.

In recent years, an increasing level of attention has been given to microglia as an important contribution to neurodegeneration in the aging brain.

Researchers here review the present state of research and use of metformin as a geroprotective drug, intended to modestly slow aging. They are largely on point, if somewhat too accepting of the quality of the existing human data.

Carrying specific HLA alleles decreases the chance of reaching healthy old age

Associations between Mediterranean lifestyle and its components with clinical outcomes among community-dwelling older adults

Sex differences in aging acceleration: higher susceptibility in women, greater preventability in men

Brain modulation interventions (BMIs) targeting cognitive and neuropsychiatric symptoms have shown substantial heterogeneity in response, limiting their clinical utility. Resting-state functional connectivity (rsFC) may capture BMI-induced neuroplasticity and support patient stratification. However, examining these biomarkers within small, heterogeneous intervention samples remains challenging.

Aging is accompanied by arterial dysfunction, defined by impaired endothelial function and increased large artery stiffness, yet the contribution of the endothelial glycocalyx (eGC) and its constituent, hyaluronan (HA), to this process remains incompletely understood.

Aging is associated with blood–brain barrier (BBB) breakdown and microvascular rarefaction, key contributors to cerebral neuroinflammation, hypoperfusion, and vascular cognitive impairment and dementia (VCID).