Reviewing the Aging of the Gut Microbiome and Interventions Known to Improve Its Composition

This AI startup, which lists Nobel laureate David Baker among its co-founders, has announced a “world model” of a cell that can simulate both its natural state and responses to successive perturbations, potentially transforming biological research.

Senescent cells accumulate with age, and actively secrete pro-inflammatory signals.

It is well established that physical fitness (and the level of activity and other lifestyle choices required to sustain it) correlate with a lower risk of mortality and longer life expectancy.

Glucagon-like peptide-1 receptor agonists engage AMPK–PGC-1α signaling to remodel mitochondrial biogenesis, dynamics, and quality control, but downstream effects are context-dependent and tissue-specific rather than uniformly receptor-proximal.

Myocardial expression of telomeric repeat-binding factor 2 (TRF2) was reduced in aged male mice and further downregulated following ischemic postconditioning (I/Post).

MSC rejuvenation strategies and functional outcomes. Aging-associated alterations in MSCs, including increased IL-6/IL-8 secretion, ROS accumulation, epigenetic drift, and mitochondrial dysfunction, impair stemness.

Deep learning applied to more than 25,000 histopathology slides revealed tissue-specific structural signatures of biological aging that tracked telomere attrition, pathology, comorbidity, and molecular changes more closely than chronological age alone.