Characterizing the SASP‐Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types

In this paper, we characterized the brain cell-type-specific SASP and defined the directionality of a paracrine spreading of senescence phenotypes. We unraveled ligand-receptor pairs underlying this spreading and showed that inhibiting this interaction ameliorates senescence dissemination.

Aging Cell · 08:10

№02 / 8 · Peter Attia

Multifactorial trials: taking apart the kitchen sink

What a multifactorial trial can prove, what it can't, and why the difference matters more than it seems

Peter Attia · 12:00

№03 / 8 · ScienceAlert

A Crucial Part of The Brain's Memory Center Seems to Shrink in People With Depression

A sign of Alzheimer’s… or a sign of something else? ScienceAlert stories are written, fact-checked, and edited by humans, never generated by AI. Don't miss a story, subscribe here.

ScienceAlert · 01:00

№04 / 8 · npj Aging

Gemfibrozil promotes longevity and health by restricting amino acid uptake through the Dipeptide transporter, PEPT1

npj Aging · 01:00

№05 / 8 · Nature Aging

Physical activity delays ovarian aging in part through adiponectin-related signaling pathways

Physical activity has geroprotective properties, yet its role in ovarian aging is incompletely understood.

Nature Aging · 01:00

№06 / 8 · Nature Aging

Exercise slows ovarian aging

Cross-sectional analyses of more than 150,000 participants show an association between higher physical activity levels and delayed menopause. In mice, physical activity can delay ovarian aging; adiponectin knockout attenuated this protection.

Nature Aging · 01:00

№07 / 8 · Nature Ageing

Histological aging signatures for monitoring tissue-specific aging and disease

Nature Ageing · 01:00

№08 / 8 · News-Medical

Youth-associated protein reverses age-related microglial changes in mice

Researchers at The Icahn School of Medicine at Mount Sinai have identified a role for the youth-associated protein TIMP2 in supporting the healthy function of microglia, the brain's resident immune cells.

News-Medical · 21:04

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