Why Do Myesthenia Gravis Patients Live Five Years Longer than the General Population?

A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and mice suggest a therapeutic route [1].

Spontaneous intracerebral hemorrhage (ICH) is a highly lethal and disabling form of stroke, in which hematoma expansion (HE) is a major and potentially modifiable determinant of early neurological deterioration and poor functional outcome.

Hutchinson–Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by de novo LMNA mutations. Patients develop severe systemic symptoms limiting life quality and ultimately causing death from cardiovascular events. Despite extensive research, treatment options remain limited.

Tauopathies emerge in the aging brain, a pathological level of phosphorylation of the tau protein that is disruptive to cell function.

Muscle tissue is metabolically active. In response to use during physical activity, muscle cells secrete a range of signals, as a class now called myokines or exerkines. These signals produce overall beneficial effects on cell behavior and tissue function throughout the body.

Aging induces sex-differential glucose intolerance, with male-specific citrulline depletion. Lactiplantibacillus plantarum AS21 elevates microbiota-derived citrulline metabolism and enhances GLP-1 secretion, improving glucose homeostasis. Aging-related metabolic decline, particularly impaired glucose tolerance, represents a growing challenge in aging populations.

Women who used estrogen-only hormone therapy later in life were less likely to develop dementia and showed fewer signs of Alzheimer’s disease in their brains, according to a large study of more than 21,000 participants.

Understanding how brain connectivity reorganizes with age is essential for characterizing healthy aging.

AI-based "tissue clocks" can estimate the biological age of human organs from histological images, researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and the Ludwig Boltzmann Institute for Network Medicine (LBI-NetMed) at the University of…

What do "epigenetic clocks" actually measure? These lab tests have become popular tools for studying biological aging, or how the body's cellular function changes at a faster or slower rate than expected.