SIRT6 Variants Found in Centenarians Produce a Lower Burden of Cellular Senescence

In a recently published perspective paper, the author argues that the UK’s official health guidelines on physical activity and protein intake should be revised to recommend levels necessary to achieve optimal health, rather than the bare minimum currently recommended [1].

The more severe later stages of Alzheimer's disease are characterized by altered forms of tau protein aggregating inside neurons to cause dysfunction, inflammation, and cell death.

The gut microbiome generates a vast range of metabolites, some beneficial or even necessary to health, and some actively harmful, provoking chronic inflammation or other dysfunction. With age the balance of microbial populations making up the gut microbiome changes for the worse.

Longevity entrepreneur Bryan Johnson shared some bad news on social media recently. “I have an autoimmune disease. My stomach is eating itself,” he wrote on X. The good news? “I’m going to try and solve it.”

Post-Traumatic Stress Disorder (PTSD) remains a common condition affecting World Trade Center (WTC) responders 25 years after the attack on the Twin Towers.

Reproductive behaviors, genetic susceptibility and accelerated aging risk

In the United States, rural communities face a particular set of challenges. Due to smaller populations and lower property values, tax revenue is often limited.

Cellular senescence has emerged as a central mechanism driving cutaneous aging, impaired regeneration, and numerous dermatologic pathologies. Initially evolved as a protective mechanism to prevent malignant transformation and facilitate wound repair, senescence becomes maladaptive when senescent cells persist.

Sirtuin 6 (SIRT6) is a protein deacetylase and ribosyltransferase that is a vital hub for maintaining epigenetic homeostasis, regulating the transcriptome, and repairing DNA double stranded breaks (DSBs). Comprehensive proteomic profiling of the SIRT6 posttranslational landscape, however, remains elusive.

Researchers at the University of Gothenburg have identified clear links between the composition of gut bacteria and frailty in older women.