A New Target Against High Blood Pressure

Telomeres are repeated DNA sequences found at the ends of chromosomes. A little telomere length is lost with each cell division, and short telomeres trigger cell senescence or programmed cell death.

Technically, even very small effects can be classed as rejuvenation if they move the right markers, if they in some way reduce the burden of damage and dysfunction of aging. Exercise probably rejuvenates to some degree, by any reasonable definition.

Researchers here discuss a bidirectional relationship between age-related alterations in bile acid metabolism, centered in the liver, and changes in the composition of the gut microbiome.

A new study reveals that aging hematopoietic stem cells trigger a form of innate immune memory, known as trained immunity, that fuels the chronic low-grade inflammation that underlies age-related physiological decline.

Targeting of RANKL by genetic and pharmacological approaches ameliorates key features of the progeroid phenotype in Zmpste24 −/− mice. RANKL intervention restores bone mass, improves muscle phenotype, and extends survival. These findings support further exploration of RANKL-targeted therapies for Hutchinson-Gilford progeria syndrome.

Breast cancer shows a bimodal age distribution with a peak at 45 and higher peak at 65. Using mice with different mitochondrial genomes, we show progressive and bimodal patterns of aging of the mammary gland with distinct pro-tumorigenic age windows.

Alter Dementia, Dementia Care Aware (DCA) and SageNavigator facilitated more than 100 free, community-based cognitive screenings at the 2026 Alter Dementia Summit and Aging Well Expo in Atlanta, Georgia, for the 100 Minds Screening Project.

Gut bacterial vesicles from the E. coliΔaroD mutant extend C. elegans lifespan

“Peptides as a class can be genuinely powerful, which is a reason to be more careful with them, not less. We can't normalize treating real drugs carelessly.” —Peter Attia