Does protein restriction still make sense in modern kidney care?

Physical activity is related to more aligned white matter fibers and microstructural reorganization of the brain. Body weight, cardiometabolic, and inflammatory factors could partly mediate the effects of physical activity on brain white matter microstructure.

Distribution-sensitive predictors of gait speed in adults aged 45–85 years in the CLSA

Despite the substantial variability in physical function among older adults, the molecular mechanisms remain poorly characterized, particularly within skeletal muscle. This study aimed to determine the patterns of DNA methylation in skeletal muscle associated with physical function in healthy older adults.

Rapamycin supplementation has been reported to extend life spans in numerous species, including Drosophila melanogaster, but a recent study in this laboratory revealed a marked life-shortening effect in y w male flies.

Background Oral anticoagulants (OACs), particularly direct oral anticoagulants (DOACs), may lower dementia risk, but existing studies are constrained by incomplete dementia ascertainment, short follow-up, and lack of evaluation of individual agents or baseline lifestyle-related risk profiles.

Dementia arises from multifactorial neurodegenerative processes, with growing evidence implicating blood–brain barrier dysfunction, neuroinflammation, and vascular injury as contributors to progressive brain tissue damage.

Metabolic dysfunction–associated steatotic liver disease (MASLD) is a common, often overlooked liver condition. Its impact on quality-of-life in older adults is not well understood.

Frailty, defined by multisystem physiological decline and heightened vulnerability to stressors, is typically associated with aging and chronic disease. However, its relevance in apparently healthy individuals remains poorly understood.

Women live longer than men in nearly every country in the world, yet they experience higher rates of disability, dementia and many other age-related conditions.