Reviewing What is Known of the Ability of Reduced Protein Intake to Slow Aging

Human Longevity Inc., a company founded in 2013 by a trio of visionaries – Craig Venter, Peter Diamandis, and Robert Hariri – initially inspired high hopes.

Calorie restriction mimetic drugs reproduce some (usually small) fraction of the beneficial metabolic changes that take place with a reduced calorie intake. An increase in the efficiency of the cellular maintenance processes of autophagy appears to be the crucial point.

The major hormones produced by the thyroid gland are broadly influential on metabolism and the function of many organs, and thyroid dysfunction is common enough in later life for this aspect of human biochemistry to be very well studied.

Sex-specific cognitive and metabolic effects of lifelong caloric restriction and sodium butyrate administration in aging rats

Effects of home-based videoconference adapted physical activity on healthy aging

Allostatic load measures the physiological consequences of stress and is associated with disease outcomes. Clinical use of allostatic load is limited, in part, because its calculation requires biomarkers not routinely measured in clinical care.

Cognitive aging is shaped by genetic variation, environmental factors, and health-related conditions. Until now, it is largely unclear why some individuals maintain their cognitive function, and others show progressive cognitive decline.

It has been hypothesized that age‑related declines in skeletal muscle and vascular function in females may be partly estrogen‑dependent.