PhenoAge Acceleration Correlates with Higher Mortality Risk Following Surgery

A new study has found that restricting dietary valine extends both median and maximum lifespan in male mice while improving healthspan in both sexes. The mechanism remains unclear, though increased liver mitochondrial activity emerged as a leading clue.

Navitoclax (or ABT-263) was one of the earliest chemotherapeutics assessed for its ability to selectively clear senescent cells as a senolytic drug.

The ability to accurately determine the composition of the gut microbiome via 16S rRNA sequencing is resulting a great deal of very interesting data on differences in the gut microbiome that are characteristic of aging, age-related diseases, and long-lived individuals.

It may seem natural to assume that people experience cognitive decline after age 90, but until recently, researchers had limited evidence about how advanced age affects the brain.

Many fear losing their independence if they agree to care workers looking after them.

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Intrinsic capacity (IC) reflects multidomain functional reserve and a measurable phenotype of healthy ageing, but its biological correlates remain incompletely understood. We examined associations of neurofilament light chain (NfL), CXCL9 and inflammatory biomarkers with IC in community-dwelling older adults.

The associations between distinct cognitive function trajectories and mortality risk, as well as the potential mediating pathway underlying this relationship, have not been fully elucidated.

Brain MRI shows promise for predicting cognitive functioning, but its utility depends on its capacity to capture stable between-person differences (e.g., patient stratification), longitudinal within-person changes (e.g., prognosis, treatment monitoring), or both.