Restoring Clearance of Neutrophils by Tissue Resident Macrophages Reverses Measures of Aging in Mice

For the last several years, Dr. José Pedro Castro, a Gladyshev Lab alumnus, who is now Assistant Researcher and Project Principal Investigator at the Institute for Research and Innovation in Health at the University of Porto, has been studying inflammation and its…

Microglia are innate immune cells of the brain, very similar to the macrophages found elsewhere in the body outside the central nervous system.

Atrial fibrillation is a disruption of normal heart rhythm. It becomes more prevalent with old age, and at its most severe end can contribute to cardiovascular mortality. Much of the incidence of atrial fibrillation is idiopathic, meaning the cause is obscure.

As a critical bioactive component of Polygonatum sibiricum, diosgenin improves age-related declines in skeletal muscle mass and function by activating the SIRT1/PGC-1α pathway, upregulating the expression of the myokine METRNL and IGF-1, and promoting satellite cell proliferation and myogenic differentiation.

Early menopause is associated with reduced global brain activity

FGF21-dependent and -independent liver transcriptomic adaptations to low-protein feeding during aging

Exploring the link between body physiology and cognition: the role of the brain and aging

Mitochondrial aggregates as a novel quality control mechanism and potential relationship to lipofuscinogenesis

Dementia is a major public health challenge, and Apolipoprotein E (APOE) ε4 is strongly associated with all-cause dementia, particularly Alzheimer’s disease (AD).

🩺 Get your personalized health plan: 📄 Full write-up & all the studies from this video: Thumbnail by James Kelly Video edited by Troy Young The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships…