Short-Term Stresses May Undermine Clock Results

Cancer is a dark mirror to the normal processes of tissue maintenance, in which normally helpful processes run amok and become pathological when harnessed to make tumors grow. A cancer is a subversion of normal regeneration and maintenance.

Clonal hematopoiesis of indeterminate potential (CHIP) is arguably the most studied form of somatic mosaicism, in which stem cells accumulate mutations over time, and thus patterns of those mutations spread out into the tissue supported by those stem cells.

The vessels of the glymphatic system run parallel to blood vessels entering the brain. Glymphatic vessels provide a path for drainage of cerebrospinal fluid into the body.

Cole and colleagues identify fructose as a component of the secretome in therapy-induced senescent ovarian cancer cells that drives metastasis.

In this Perspective, the authors envision that agentic AI systems may in the future support clinical workflows for neurodegenerative disease diagnosis and care.

Using plasma proteomics, Yu, Chen, Feng, Li et.

A plasma proteomic signature enables accurate prediction of metabolic dysfunction-associated steatotic liver disease (MASLD) up to 16 years before diagnosis, and offers a clinically applicable proteomic framework for early risk stratification and preventive intervention.

Programmatic adaptive failure in myeloid cells: a hypothesis-generating framework linking frailty to accelerated epigenetic aging

Declines in nicotinamide adenine dinucleotide (NAD+) are linked to metabolic stress accompanying aging and disease. While precursor-based approaches elevate systemic NAD, their clinical translation can be constrained by biosynthetic bottlenecks and first-pass metabolism.