How the Immune System Makes Sun Damage Worse

As the name might suggest, aquaporin proteins facilitate the transfer of water molecules across cell membranes.

The immune system and its supporting organs and structures throughout the body, such as bone marrow, spleen, lymphatic system, and thymus, are collectively make up a very complex system. The way in which the immune system ages is thus also very complex.

Clonal hematopoiesis of indeterminate potential (CHIP) is a form of somatic mosaicism in the immune system.

Using an aged rat model, patient tissue samples and patient-derived organoids, Carleton et al. profiled age-associated differences in estrogen receptor-positive breast cancer, identifying inflammation and altered estrogen metabolism as possible contributors to age-related tumor permissiveness.

“The history of medicine is full of examples where we didn't invent the underlying mechanism. We discovered it, understood it, and then engineered it into something useful.” —Peter Attia

University of California, Davis Professor of Neurology Sarah Tomaszewski Farias has been awarded a $3.3 million five-year grant from The National Institute on Aging to study if cultural differences affect how people perceive cognitive changes as they age.

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Age-related downregulation of AcSirt2 impairs mitochondrial homeostasis in old bees. AcSirt2-mediated deacetylation of FOXO enhances transcriptional activity, upregulating antioxidant enzymes (SOD, CAT) and promoting PINK1/Parkin-mediated mitophagy. This pathway facilitates autophagosome formation and clearance of damaged mitochondria, reducing ROS accumulation.