p38 MAPK and MDT-15 mediate SKN-1-dependent metformin-induced protection against mitis group streptococci in Caenorhabditis elegans

Aging is accompanied by progressive epigenetic alterations, including changes in DNA methylation affecting both gene-associated regions and repetitive elements such as LINE-1 retrotransposons. Reduced epigenetic repression of transposable elements has been implicated in age-related genomic instability.

Apiotrichum-centered gut fungal network disturbance correlates with increased arterial stiffness. Five driver genera including Apiotrichum, Mycothermus, Flavocillium, Hyaloscypha, and Microscypha regulate the interaction shift.

A systemic single-cell and spatially-resolved transcriptomics and TCR sequencing analysis across the aging thymus dissects the molecular underpinnings of T cell subset dynamics. The study highlights the shifting proportions and transcriptomic profiles of T cell subsets during aging.

We developed plasma protein-based musculoskeletal aging clocks, MSKAge and MSKAgeMort, using UK Biobank proteomic data, and showed that MSKAgeAccel and MSKAgeMortAccel (in particular) predicted mortality, musculoskeletal disorders, and age-related diseases effectively.

Results from a small clinical trial suggest it may be possible to reduce your risk of dementia by eating during fewer hours of the day.

Scientists have identified a possible tipping point that helps determine whether Alzheimer’s-related brain changes lead to dementia.

Researchers at Revel Pharmaceuticals and Calico Life Sciences have engineered CMLase, an enzyme that removes carboxymethyl-lysine (CML) — a glycation product long considered permanent damage on our longest-lived proteins.

CLC-1 Inhibition Improves the Function of Neuromuscular Junctions in Aging Muscle The Aging Immune System Disrupts Maintenance of Bone Tissue Quantifying the Risk of Alzheimer's Disease Associated with High Levels of p-tau217 in Blood Gut Microbiome Composition Correlates with Epigenetic Clock Results