How Muscle Loss and Bone Loss Are Related

Researchers have elucidated some of the links between the age-related loss of muscle (sarcopenia) and the age-related loss of bone (osteoporosis). Substantial previous research has described the relationship between muscle and bone health.

Lifespan.io · 20:17

№02 / 40 · Fight Aging!

Better Understanding the Immunomodulatory Effect of the Longevity Associated Variant of BPIFB4

In recent years, researchers have noted that one variant of the BPIFB4 gene is associated with human longevity.

Fight Aging! · 19:41

№03 / 40 · Fight Aging!

A Better Approach to Screening for Existing Drugs that Slow Aging

The nature of medical regulation makes it extremely expensive to develop a new drug, and considerably less expensive to find a new use for an existing approved drug.

Fight Aging! · 11:22

№04 / 40 · Fight Aging!

Dunedin Pace of Aging Clock Responds to Lifestyle Interventions

Aging clocks cannot be trusted to produce useful data for any novel intervention in aging.

Fight Aging! · 11:02

№05 / 40 · Aging Cell

Metabolic Kinases as Regulators of Inter‐Organelle Communication in Aging and Age‐Related Diseases

Metabolic kinases integrate cellular energy, nutrient, and stress signals to regulate inter-organelle coordination during aging.

Aging Cell · 04:04

№06 / 40 · Peter Attia

Building strength and muscle mass: how to optimize training, nutrition, and more for longevity (AMA #71 rebroadcast)

“The more you move, the more you’re alive. The less you move, the less you’re alive.” —Peter Attia

Peter Attia · 05:15

№07 / 40 · GeroScience

Emergence of heartbeat frailty in advanced age II: individual cardiovascular aging trajectories revealed by lifelong echocardiography in male mice

Chronological age is the strongest risk factor for cardiovascular disease, yet individual trajectories of cardiovascular aging, particularly during late life, remain incompletely characterized.

GeroScience · 01:00

№08 / 40 · GeroScience

The dual diversity crisis in alzheimer's disease research: why neuroimaging biomarkers and clinical trials keep failing

Alzheimer's disease clinical trials have failed at a rate exceeding 99% over two decades, and neuroimaging biomarkers developed in discovery cohorts have repeatedly disappointed in validation and clinical application. Standard explanations address symptoms rather than structural causes.

GeroScience · 01:00

№09 / 40 · GeroScience

Impact of mixed reality on the care of the elderly: a scoping review

Population aging requires innovative technological strategies that promote autonomy, functionality, and well-being in old age. In this context, mixed reality (MR), a technology that integrates physical and digital elements in a shared and interactive real-time environment, emerges as a promising alternative.

GeroScience · 01:00

№10 / 40 · News-Medical

BCG vaccine may remodel the human brain's immune environment

New research led by Mass General Brigham investigators suggests that the Bacillus Calmette-Guérin (BCG) vaccine - which is delivered through the skin to prevent tuberculosis - may remodel the human brain's immune environment, offering a potential biological explanation for previously observed associations…

News-Medical · 12:47

№11 / 40 · News-Medical

Uterine aging may reduce donor egg pregnancy success after 49

A major new study suggests that age-related changes in the uterus may contribute to poorer pregnancy outcomes, with women aged 49 and over experiencing lower live birth rates and higher miscarriage risk despite donor-oocyte treatment.

News-Medical · 03:56

Also today · №12–40

№12 · Fight Aging! · 11:11

Senescent Cells in Senile Lentigo Caused by UV Exposure

Senile lentigo, an age spot, is a form of photoaging in response to UV exposure featuring…
№13 · News-Medical · 12:46

USC scientists target brain inflammation to prevent Alzheimer's disease

An interdisciplinary team at the USC Center for Personalized Brain Health (CPBH) is targeting a family…
№14 · New Atlas · 06:49

Lifespan-extending human trial to rejuvenate old and tired immune cells

A landmark study due to start in the coming months aims to test a method for…
№15 · Aging Cell · 04:08

Bidirectional Relationship and Shared Mechanisms Between Sarcopenia and Osteoporosis: An Observational Study Integrating Genomic, Proteomic, and Metabolomic Data

This study investigated the bidirectional relationship and shared mechanisms between sarcopenia and osteoporosis using data from…
№16 · Nature Ageing · 01:00

Influence of high-fat diet and sex on connective tissue in carpal tunnel syndrome
№17 · News-Medical · 02:53

Depression-like behavior may accelerate endocrine aging in primates

A new review was published in Volume 18 of Aging on June 11, 2026, titled "Age-related…
№18 · Lifespan.io · 17:21

Study Maps Existing Drugs to the Hallmarks of Aging

A new study suggests a way to predict whether existing drugs can extend human lifespan. This…
№19 · News-Medical · 17:49

Alzheimer’s disease biomarkers predict rapid cognitive decline in very old adults

Cognitive decline in very old adults has been considered for decades to be an almost inevitable…
№20 · Physionic · 13:00

More Exercise = More Plaque ▶

Exercise is still good for your heart — but very high-volume endurance training may not be…
№21 · Nature Aging · 01:00

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging

Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and…
№22 · Nature Aging · 01:00

Inhibition of telomere damage signaling restores hematopoiesis and immune function

We show that telomeric DNA damage signaling substantially contributes to hematopoietic aging.
№23 · MIT Tech Review · 18:36

Roundtables: Longevity’s Next Frontier: “Reprogramming” Your Body

Billions of dollars are flooding into efforts to reverse aging as scientists explore ways to return…
№24 · Aging Cell · 05:11

Clonal Analyses Reveal the Impact of Hematopoietic Stem and Progenitor Cell Aging on T Cell Development

This study explored whether the decline in thymic output with age is due to intrinsic defects…
№25 · Aging Cell · 04:57

A Gut‐Centric View of Ageing: A Pilot Analysis Mapping Age‐Associated Immune and Molecular Alterations in Colonic Mucosa Using Spatial Proteomics

Spatial proteomics reveals age-associated changes in the gut mucosa.
№26 · Lifespan.io · 22:02

How a Primate-Specific RNA Strand Worsens Senescence

Researchers have discovered a primate-specific piece of non-coding RNA that is linked to aging and makes…
№27 · ScienceDaily Aging · 08:21

Scientists may have finally found how Alzheimer's spreads through the brain

A common brain protein may be giving Alzheimer’s disease an unexpected way to spread, carrying toxic…
№28 · GeroScience · 01:00

Age-related differences in motor unit discharge rate modulation across contraction levels

Age-related strength loss may reflect morphological and neural adaptations that differ between muscles. However, it is…
№29 · GeroScience · 01:00

The influence of aging on graded peripheral venous return and complex blood flow features through human veins

Aging is associated with reduced venous compliance and altered muscle pump function, though how these features…
№30 · Brad Stanfield · 17:46

The Anti-Aging Supplement Everyone Took Never Worked ▶

🩺 Get your personalized health plan: 📄 Full write-up & all the studies from this video…
№31 · Lifespan.io · 18:13

Rejuvenation Roundup June 2026

Doing something about aging seems to require action at the most basic genomic level. Here’s what’s…
№32 · Nature Ageing · 01:00

Mitochondrial quality control in human ageing and longevity
№33 · Nature Ageing · 01:00

Diapause presses pause on life’s developmental and ageing clock
№34 · Nature Ageing · 01:00

Audio long read: Is the peptide craze backed by science? The promise behind the hype
№35 · npj Aging · 01:00

Motor unit behavior adaptations across lifespan: sex differences in young, middle-aged and old adults

Motor unit behavior adaptations across lifespan: sex differences in young, middle-aged and old adults
№36 · npj Aging · 01:00

The evolution of aging research: from theories to epigenetic reprogramming

The evolution of aging research: from theories to epigenetic reprogramming
№37 · Peter Attia · 05:15

#398 ‒ AMA #86: GLP-1 RAs and muscle loss: new data, better questions, and how to preserve muscle during weight loss

“When patients are counseled thoroughly on how to consume protein [in the right amount] and how…
№38 · GeroScience · 01:00

Long-term intake of statins or renin-angiotensin system inhibitors: associations with sarcopenia-related parameters in older people

The long-term impact of common cardiovascular medications on sarcopenia in older people is unclear.
№39 · GeroScience · 01:00

Study protocol for FAXAge: a randomized, controlled clinical trial of fasting and exercise to slow aging in humans

Biomarkers of aging, particularly DNA methylation-based clocks, have shown promise as tools to assess whether interventions…
№40 · GeroScience · 01:00

The shaky voice of aging localized to the larynx: dissociation of frequency and amplitude tremor

Aging is associated with structural and functional changes of the vocal folds that may result in…

Edition №02 complete

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Aggregated longevity news, not medical advice. Consult a clinician before acting on anything you read here.