Small Molecule GPR40 Agonism Restores Thymic Activity in Aged Mice

According to the experts that we spoke to, the death, which followed an intravenous NAD⁺ infusion that went catastrophically wrong, underscores the risks of unproven treatments and the need for rigorous longevity medicine.

A number of neurodegenerative conditions, including Alzheimer's disease, are characterized by a pervasive chemical alteration of tau protein that causes tau to cease its normal function and aggregate into structures known as neurofibrillary tangles.

One of the hallmarks of dysfunctional lipid metabolism in the brain the context of age-related neurodegenerative disease is an increase in lipid droplets in brain cells. This is seen in a number of different neurodegenerative conditions.

FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis

Royal jelly ameliorates age-associated stem cell dysfunction with Chi3l1-mediated increase in CD206-positive macrophages

The blood proteome predicts the impact of circulating factors on age-related mitochondrial health

Neutrophil extracellular traps (NETs) play a pivotal role in UVB-induced skin photodamage. Mechanistically, NETs bind to the CCDC25 receptor on keratinocytes and subsequently activate the intracellular p-JNK/JNK signaling pathway, thereby exacerbating skin photodamage. The pathogenesis of skin photodamage remains incompletely elucidated.

Age-related endothelial dysfunction in the cerebral microcirculation contributes significantly to the pathogenesis of vascular cognitive impairment and dementia (VCID).

The longevity-linked APOE2 gene appears to protect brain cells by reducing DNA damage and helping neurons recover from stress. The finding could open a new path toward treatments that mimic APOE2’s defenses in people at higher genetic risk for Alzheimer’s.