Mismatch Between Between Nuclear and Mitochondrial DNA Modestly Accelerates Aging in Flies

Scientists have engineered an enzyme that removes an advanced glycation end product (AGE) from proteins. This type of age-related modification, which affects protein function and can trigger inflammation, has previously been considered extremely hard to reverse [1].

You might recall that last year researchers demonstrated an age-related decline in peroxisome number in cells. Peroxisomes carry out a range of functions related to oxidative and lipid metabolism, but are relatively poorly researched in the context of aging.

That evolution does not optimize for species longevity is illustrated by the large number of small alterations in gene sequence or protein level that extend life in short-lived laboratory species such as nematode worms.

Schematic summary of the protective effects of HucMSC-derived exosomes (HucMDEs) against aging-related hepatic lipid metabolism disorders through autophagy enhancement. Health problems associated with aging have become increasingly severe in recent years.

AI is transforming biology and it can now design antibodies from scratch.

Age-related pure-tone hearing loss (HL) frequently co-occurs with central auditory processing deficits and cognitive decline and is commonly associated with speech processing difficulties.

Collateral circulation that determines infarct progression in large vessel occlusion (LVO) is implicitly regarded as stationary. We investigated collateral circulation changes during interfacility transfer for endovascular thrombectomy (EVT) and its association with functional outcome in anterior circulation LVO stroke.

A drug originally developed for spinal cord injury may offer a fresh approach to treating Alzheimer’s disease. In mouse studies, KCL-286 repaired dangerous DNA damage, reduced inflammation, and targeted multiple disease-related pathways instead of focusing on just amyloid or tau.

Ribonuclease K (RNASEK) maintains ribostasis by degrading circular RNAs (circRNAs) in young cells, enabling functional stress granules (SG) and proper RNA-protein metabolism for healthy aging and longevity.