Proposing the Synergy of Therapeutic Plasma Exchange and Partial Epigenetic Reprogramming

Loss of muscle mass and quality (myopenia and myosteatosis) are hallmarks of aging and predictors of disability, yet their relationship with biological aging in younger adults is unclear.

This study applied Ward’s hierarchical clustering to detailed neuropsychological data from a community-recruited sample of 180 older adults to identify naturally occurring cognitive subgroups and characterize multidomain cognitive heterogeneity beyond conventional mild cognitive impairment (MCI) criteria.

A new study suggests that aging or Parkinson’s-triggering mutations create inflammation in peripheral tissues, and then circulating extracellular vesicles spread it to the brain, which might contribute to the disease [1].

Every mechanism of aging influences all of the other mechanisms of aging. Our biology is a big tangled ball of interactions.

STING is a master regulator of inflammatory signaling, triggered by a range of different sensor proteins for foreign material or forms of damage within a cell.

Macedo et al. report the longitudinal spatiotemporal dynamics of tau from positron emission tomography.

GW9508 activates GPR40 to trigger Ca2+ influx and AMPKα signaling, repressing ERK1/2-MAPK cascade. This pathway alleviates thymic epithelial cell senescence and restores T cell production to counteract thymus aging.

Aging selectively enhances mechanical alloknesis. This is associated with altered systemic serotonin homeostasis and increased 5-HT7 receptor expression in dorsal root ganglion neurons and spinal dorsal horn (laminae III–IV). Pharmacological inhibition of serotonergic signaling attenuates itch behavior.

Rapid scientific progress has given us the tools to stop time more convincingly than ever – but lurking behind these claims is the same fear of ageing Andrea holds a PhD in literature and works for a non-profit in Dallas.

Studies on the proteostasis network and aging have focused on protein synthesis, folding, and turnover. Here, emphasis on the spatial dimension in proteostasis is proposed by recognizing nucleocytoplasmic transport as an important player in aging.