Metformin and cancer: active surveillance needed

Metformin failed in prostate cancer and many others—but exceptions remind us to think with precision about interventions

Peter Attia · 12:00

№02 / 40 · Aging Cell

A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Aging-associated MLKL upregulation in hepatocytes induces mitochondrial dysfunction and oxidative stress, accompanied by increased release of pro-inflammatory extracellular vesicles.

Aging Cell · 04:18

№03 / 40 · npj Aging

Biological aging increases risk of postoperative morbidity and mortality: an international, multi-cohort study

npj Aging · 01:00

№04 / 40 · Fight Aging!

Knowledge is More a Barrier than Wealth When it Comes to Access to Treatments for Aging

Ethicists seem a little stuck on the idea that treatments to slow and potentially reverse aspects of aging are only available to the wealthy, or will only be available to the wealthy.

Fight Aging! · 19:27

№05 / 40 · Lifespan.io

Intermittent Fasting Increases Lifespan in Male Mice

Restricting food access to an 8-hour window increased median lifespan in male mice by 12%. However, that might be due to voluntary caloric restriction induced by the regimen [1].

Lifespan.io · 17:33

№06 / 40 · GeroScience

Associations of IL-17 and TGF-β1 with physical frailty in older adults

Background Physical frailty is a prevalent geriatric syndrome associated with reduced physiological resilience and adverse outcomes. Beyond classical inflammaging, age-related changes in immune regulation and tissue repair may contribute to frailty pathophysiology.

GeroScience · 01:00

№07 / 40 · Fight Aging!

A Mechanism to Explain the Age-Related Failure to Resolve Fibrosis in the Lung

Pulmonary fibrosis is an age-related condition. Good evidence connects it to the burden of senescent cells in the aging lung, but its causes are otherwise relatively poorly understood. Therapeutic options remain poor, and the prognosis for patients is quite ugly.

Fight Aging! · 11:22

№08 / 40 · Fight Aging!

Fitting a Damage Accumulation Model of Aging to Variations in Species Life Span

If used sensibly, models of aging can offer some insight into the bounds of the possible with regard to which classes of biological mechanism are more or less important in determining pace of aging, onset of disease, and life span.

Fight Aging! · 11:11

№09 / 40 · ScienceDaily Aging

Drinking to cope with stress may permanently rewire your brain

Using alcohol to cope with stress when young may permanently alter the brain, making it harder to adapt to challenges and increasing the risk of returning to drinking later in life.

ScienceDaily Aging · 00:43

№10 / 40 · Aging Cell

EGR1 Mediates Ursodeoxycholic Acid‐Promoted Mitophagy to Prevent Postovulatory Aging of Porcine Oocytes

This study delivers dual key advances: mechanistically, we uncover a novel role of EGR1 as a pivotal transcriptional regulator that bridges upstream gene expression dysregulation to downstream mitophagic decline in oocyte aging; and translationally, we validate the therapeutic potential of the clinical…

Aging Cell · 13:42

№11 / 40 · Nature Aging

Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle

Exercise has an important role in healthy aging, yet the underlying molecular mechanisms are incompletely understood. Here the authors consider age, physical function and acute exercise in the context of the multiomics of human skeletal muscle, linking fitness to distinct aging profiles.

Nature Aging · 01:00

Also today · №12–40

№12 · Nature Aging · 01:00

Therapeutic targeting of the conserved region within the low-complexity domain of TDP-43 is neuroprotective and extends survival in amyotrophic lateral sclerosis mice

Gao et al. identify a toxicity-driving region within TDP-43 and show that a brain-penetrant small molecule…
№13 · Nature Aging · 01:00

Age-related molecular changes that are exercise independent

Multiomics analysis of human muscle suggests that physical fitness reshapes age-related molecular changes, and highlights distinct…
№14 · ScienceDaily Aging · 19:54

Scientists discover why some brains resist Alzheimer's

Some brains appear to fight back against Alzheimer's by helping immature brain cells survive damage instead…
№15 · Fight Aging! · 12:07

Fight Aging! Newsletter, July 6th 2026

NOX4 in the Age-Related Decline of Muscle Adaptation to Exercise Using Secreted Proteins to Map Burden…
№16 · Aging Cell · 08:09

Interplay of the ENS and Microbiota With Murine Gut Epithelium‐Derived Organoids in Aging

A gut organoid model was developed to study the impact of age-related changes of the enteric…
№17 · npj Aging · 01:00

Telomere integrity, epigenetic aging, and genetic burden shape biological aging trajectories in idiopathic pulmonary fibrosis

Telomere integrity, epigenetic aging, and genetic burden shape biological aging trajectories in idiopathic pulmonary fibrosis
№18 · Fight Aging! · 19:22

Intermittent Hypoxia Transiently Increases Epigenetic Age in Old Mice

Intermittent mild hypoxia has been shown to slow aging and improve health in animal studies, and…
№19 · ScienceDaily Aging · 09:42

The real cause of a common stroke may have been missed for decades

Scientists have discovered that a common type of stroke may have a very different cause than…
№20 · GeroScience · 01:00

Spatiotemporal profiling of white matter lesions and their contribution in the pathologies of Parkinson’s disease animal models

Increasing evidence has identified significant white matter lesions (WMLs) in Parkinson’s disease (PD) patients. However, the…
№21 · GeroScience · 01:00

PROMETHEUS clinical trial protocol: tailoring healthy ageing with lifestyle and nutraceuticals

The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. Precision…
№22 · News-Medical · 16:50

Study reveals how specific aging cells help repair injured tendons

Tendon injuries, though very common, frequently heal with scar tissue, which is less flexible and more…
№23 · Fight Aging! · 11:22

Self-Experimentation to Slow Aging is Rarely Presented in a Good Light

Sadly, we live in an age in which the media likes to generate conflict, and in…
№24 · Fight Aging! · 11:11

Evidence for Hematopoietic Progenitor Cells to Buffer the Aging of Hematopoietic Stem Cells

Hematopoietic cell populations reside in the bone marrow. A tree of ever more specialized progenitor cell…
№25 · Nature Aging · 01:00

Modulating IL-11-dependent matrix stiffness to delay ovarian aging

The ovarian stroma becomes increasingly stiff with age, impairing ovarian function. The mechanisms that underlie this…
№26 · Nature Aging · 01:00

Mapping the network architecture of aging to identify repurposable drug candidates for longevity

A network medicine framework reveals that the hallmarks of aging form interconnected molecular modules in the…
№27 · Nature Aging · 01:00

Targeting interleukin-11 to slow ovarian aging

As ovaries age, the ovarian stroma — the connective tissue in which follicles are embedded …
№28 · Aging Cell · 07:47

Age‐Associated Senescence of Decidual Macrophages: A Key Mediator of Adverse Pregnancy Outcomes in Advanced Maternal Age

Decidual macrophages (DM) in advanced maternal age (AMA) exhibit FOXO3 deficiency-driven senescence, further accelerated by elevated…
№29 · News-Medical · 03:22

Psychological stress accelerates immune aging through the gut microbiota

Psychological stress is increasingly recognized as a risk factor for certain health conditions including cardiovascular disease…
№30 · Aging Cell · 01:31

Correction to “Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction”

Aging Cell, Volume 25, Issue 7, July 2026.
№31 · npj Aging · 01:00

The cancer Alzheimer’s disease paradox

A paradoxical inverse correlation between cancer and Alzheimer’s disease has been repeatedly observed in epidemiological studies.
№32 · Brad Stanfield · 20:53

Should You Take Vitamin K2? (New Trial) ▶

🩺 Get your personalized health plan: 📄 Full write-up & all the studies from this video…
№33 · Fight Aging! · 19:22

Why Gene Therapies Targeting Longevity-Related Genes are Not Yet Widespread

Genes produce proteins at a pace determined by epigenetic control over nuclear DNA structure. That epigenetic…
№34 · GeroScience · 01:00

Homebound status and glycemic control among older adults: results from a national survey

Despite well-documented poor health outcomes among homebound older adults with diabetes, little is known about how…
№35 · GeroScience · 01:00

Adipokines and satiety hormones and incidence of Alzheimer’s disease and dementia in older adults: a nested case-control study

Obesity is known to have an intricate relationship with the development of Alzheimer’s disease and dementia…
№36 · GeroScience · 01:00

Longitudinal lipidomic markers of cardiac aging and risk of coronary heart disease in American Indians: the Strong Heart Family Study

Age-related decline in left ventricular (LV) diastolic function is a hallmark of cardiac aging and an…
№37 · Physionic · 13:00

Cure Insomnia: Use this Science backed Therapy ▶

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders: *EMAIL LIST* 1-2 Weekly Email of…
№38 · Fight Aging! · 11:22

Reduced FOXO1 in Epididymal Tissue as a Proximate Cause of Male Reproductive Aging

In mammals the male reproductive system outlasts the female reproductive system over the course of aging…
№39 · Fight Aging! · 11:11

Senescent Cells in Senile Lentigo Caused by UV Exposure

Senile lentigo, an age spot, is a form of photoaging in response to UV exposure featuring…
№40 · News-Medical · 12:46

USC scientists target brain inflammation to prevent Alzheimer's disease

An interdisciplinary team at the USC Center for Personalized Brain Health (CPBH) is targeting a family…

Edition №01 complete

Return tomorrow.
Live longer.

Aggregated longevity news, not medical advice. Consult a clinician before acting on anything you read here.